{"id":"W3168019520","doi":"10.1158/1557-3265.ovcasymp18-gmm-027","title":"Abstract GMM-027: DYNLL1 INHIBITS DNA END RESECTION IN BRCA1-DEFICIENT CELLS AND REGULATES PARP INHIBITOR SENSITIVITY","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Olaparib; Cancer research; Homologous recombination; DNA repair; PARP inhibitor; Genome instability; Ovarian cancer; Cisplatin; Chemistry; Molecular biology; Germline; Ovarian carcinoma; DNA damage; DNA; Poly ADP ribose polymerase; Cancer; Biology; Polymerase; Genetics; Gene; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583465,0.0002944365,0.000398758,0.0002577094,0.0002587,0.0004372242,0.0003553985,0.0004287341,0.002213915],"category_scores_gemma":[0.0001365839,0.0001593652,0.0002464569,0.0001481761,0.0002992461,0.0001446542,0.0003020974,0.0006332868,0.0009043537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005280629,"about_ca_system_score_gemma":0.0003562769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009936194,"about_ca_topic_score_gemma":0.001579262,"domain_scores_codex":[0.9997985,0.00002260634,0.0000245736,0.00005880314,0.00005225284,0.00004342162],"domain_scores_gemma":[0.9998503,0.00002513358,0.00004315897,0.00001581965,0.00001400047,0.00005163242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001794453,0.00005816571,0.0005459439,0.00008271415,0.000007907922,0.000121702,0.00001754714,0.0001332183,0.9965071,0.0001034874,0.0003486635,0.001893961],"study_design_scores_gemma":[0.00003875397,0.000327188,0.005294636,0.0000111039,0.00002139785,0.0003828387,0.00005333516,0.001561613,0.9841813,0.00003545577,0.008079764,0.00001274523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797813,0.003970102,0.006641453,0.0006112001,0.000180097,0.0001336872,0.0037276,0.0009465888,0.004007966],"genre_scores_gemma":[0.9889117,0.0006841448,0.002457732,0.0002162224,0.00001105101,0.00006921864,0.002390385,0.00006611961,0.005193241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002213915,"threshold_uncertainty_score":0.007406294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04839840193250962,"score_gpt":0.4420433500958578,"score_spread":0.3936449481633482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}