{"id":"W3168032537","doi":"10.2139/ssrn.3817810","title":"Live Imaging of SARS-CoV-2 Infection in Mice Reveals Neutralizing Antibodies Require Fc Function for Optimal Efficacy","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Western University; Université du Québec à Montréal; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"Antibody; Coronavirus disease 2019 (COVID-19); Virology; Immune system; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); In vivo; Effector; Neutralizing antibody; Medicine; Nasal administration; Neutralization; Biology; Infectious disease (medical specialty); Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002773048,0.0005219673,0.0003140614,0.0002145812,0.000178116,0.0004178944,0.0003255134,0.0008237087,0.001934309],"category_scores_gemma":[0.0001758369,0.0002960528,0.0002858579,0.0001081216,0.0002414885,0.0005663046,0.0001535432,0.001337771,0.0006741526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000514738,"about_ca_system_score_gemma":0.0002537298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134332,"about_ca_topic_score_gemma":0.001411032,"domain_scores_codex":[0.9997985,0.00002439733,0.000009160078,0.00004194647,0.00003878811,0.0000872552],"domain_scores_gemma":[0.9999015,0.00002327712,0.00002733054,0.000009553804,0.00001828832,0.0000200505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001070524,0.00002340816,0.00007277376,0.00001666015,0.000003667646,0.00001980056,0.000008959511,0.00006306212,0.9986184,0.0001226381,0.00006855552,0.0008750725],"study_design_scores_gemma":[0.00002977269,0.0003338901,0.002339938,0.0000088325,0.00001312209,0.0002518806,0.00002927834,0.002822516,0.9925512,0.0001352666,0.001478727,0.000005525925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625705,0.003711191,0.02275876,0.0007702495,0.00009697444,0.00008629857,0.0006627891,0.000292685,0.009050446],"genre_scores_gemma":[0.9788194,0.001223981,0.01336317,0.0002949507,0.00003060908,0.00005861163,0.000709401,0.00008528835,0.005414495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001934309,"threshold_uncertainty_score":0.006470919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911333104076933,"score_gpt":0.3629899170925969,"score_spread":0.3238765860518276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}