{"id":"W3168045009","doi":"10.3390/cancers13122922","title":"Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Breast Cancer Society of Canada; Dalhousie Medical Research Foundation","keywords":"PI3K/AKT/mTOR pathway; Breast cancer; Medicine; Glycolysis; Cancer research; Cancer; Internal medicine; Discovery and development of mTOR inhibitors; Protein kinase B; Oncology; Signal transduction; Biology; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003424821,0.0006018095,0.000986691,0.001662741,0.0001864669,0.0007081972,0.0005854956,0.0007254542,0.003231444],"category_scores_gemma":[0.0004279069,0.0002115958,0.0005412517,0.001307416,0.0002129424,0.0008263804,0.0005099059,0.001448695,0.00160316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004678807,"about_ca_system_score_gemma":0.0007203021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007865825,"about_ca_topic_score_gemma":0.001806858,"domain_scores_codex":[0.9998827,0.00002105552,0.00001677718,0.0000177589,0.00004600404,0.00001566702],"domain_scores_gemma":[0.9998784,0.00005024501,0.00002150374,0.000003298637,0.00003348403,0.00001312538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001133105,0.00008558492,0.0001416062,0.02186319,0.0001213023,0.0001979242,0.00004560278,0.0003724727,0.002043029,0.002889579,0.03506492,0.9370615],"study_design_scores_gemma":[0.00002771775,0.0001693353,0.0007788585,0.004441721,0.0001659386,0.001219246,0.00003843897,0.0001241333,0.0006187595,0.001571005,0.9908292,0.00001570044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001142224,0.9989103,0.00004634403,0.0001652634,0.0001254382,0.000003466622,0.00001366291,0.000005285247,0.0006160346],"genre_scores_gemma":[0.0005263489,0.9987746,0.00006470589,0.0001273778,0.00007747154,0.000003978368,0.00002319149,8.53516e-7,0.0004015725],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003231444,"threshold_uncertainty_score":0.01081026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05457637850732933,"score_gpt":0.4224668694947123,"score_spread":0.367890490987383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}