{"id":"W3168048598","doi":"10.3233/bd-201056","title":"The effect of IL-1β on MRP2 expression and tamoxifen toxicity in MCF-7 breast cancer cells","year":2021,"lang":"en","type":"article","venue":"Breast Disease","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Multidrug resistance-associated protein 2; Tamoxifen; Breast cancer; Estrogen receptor; MCF-7; Medicine; Cancer research; Carcinogenesis; Internal medicine; Metastasis; Antiestrogen; Inflammation; Cancer; Endocrinology; Biology; Transporter; ATP-binding cassette transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720863,0.0003311808,0.0003548079,0.0002620444,0.0002135662,0.0002543639,0.0001138291,0.0002541305,0.001663255],"category_scores_gemma":[0.00009523948,0.0001238461,0.0004343023,0.0003182525,0.0001943158,0.0001876677,0.0001062283,0.0006382363,0.0004529396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201099,"about_ca_system_score_gemma":0.0001787719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005333308,"about_ca_topic_score_gemma":0.0008894382,"domain_scores_codex":[0.9997801,0.00003362283,0.00002535597,0.00003488884,0.00007454461,0.00005152324],"domain_scores_gemma":[0.9998931,0.00002246281,0.00002800977,0.000009686354,0.00003084512,0.00001587638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002781022,0.0001007034,0.0006454951,0.0001939819,0.0000142969,0.00011444,0.00005980225,0.0000606681,0.9967685,0.00005302851,0.0001901278,0.001520945],"study_design_scores_gemma":[0.0000719704,0.002266762,0.02074014,0.00003186599,0.00006937489,0.0006546268,0.0002286438,0.0007359299,0.9679949,0.00007629091,0.007112744,0.00001682659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796755,0.01206087,0.002130995,0.0006020718,0.0001629724,0.00007175651,0.002111166,0.00009900604,0.003085685],"genre_scores_gemma":[0.9833685,0.006587664,0.002818757,0.0002661945,0.00006404144,0.0002374683,0.002918466,0.00001506035,0.003723923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663255,"threshold_uncertainty_score":0.005564213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003602639988325862,"score_gpt":0.2322221336590548,"score_spread":0.228619493670729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}