{"id":"W3168166301","doi":"10.1042/cs20210059","title":"Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?","year":2021,"lang":"en","type":"article","venue":"Clinical Science","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Endothelial dysfunction; Cancer; Breast cancer; Cardiotoxicity; Context (archaeology); Cardiac function curve; Endothelium; Bioinformatics; Biomarker; Internal medicine; Heart failure; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008868204,0.0002414258,0.0007837001,0.0003401864,0.0002550996,0.001488897,0.0002808082,0.0009674338,0.002256667],"category_scores_gemma":[0.001268148,0.00008884916,0.0003165567,0.0003359806,0.0007662004,0.0010465,0.0004361178,0.001687089,0.0003692125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004439885,"about_ca_system_score_gemma":0.0005946496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003029659,"about_ca_topic_score_gemma":0.0004982335,"domain_scores_codex":[0.9996955,0.0001156719,0.00002978861,0.00004885531,0.00006315591,0.00004700704],"domain_scores_gemma":[0.9994,0.000297921,0.0001091349,0.0000210001,0.0001212722,0.00005063852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001121631,0.0002601348,0.01633001,0.009532686,0.0005362146,0.00219937,0.0006375494,0.0009214806,0.02566067,0.03836628,0.04036273,0.8640712],"study_design_scores_gemma":[0.0001805134,0.001842576,0.06667977,0.00797462,0.0009698014,0.01415646,0.00212232,0.002066174,0.02529685,0.05435888,0.8241902,0.0001618073],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01443436,0.9567491,0.00238531,0.01988436,0.001320761,0.00001804943,0.0001491005,0.00003678391,0.005022215],"genre_scores_gemma":[0.1340154,0.850741,0.001063889,0.007808338,0.003307946,0.00003395095,0.0001756966,0.00001465703,0.00283911],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002256667,"threshold_uncertainty_score":0.007549286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926217672329264,"score_gpt":0.3455057436965961,"score_spread":0.3062435669733035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}