{"id":"W3168174363","doi":"10.1101/2021.06.01.445760","title":"Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"HDAC6; Acetylation; Cancer research; Histone deacetylase; Lymphoma; Biology; Histone deacetylase inhibitor; B cell; Histone; Chemistry; Gene; Biochemistry; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009164314,0.0002823203,0.000179704,0.0001876172,0.00008202594,0.0002398318,0.0002513526,0.0001825026,0.001131773],"category_scores_gemma":[0.00004295502,0.0001206427,0.0001679861,0.0001282938,0.000122942,0.0001219758,0.000176586,0.0005100627,0.0004889001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002662496,"about_ca_system_score_gemma":0.0001011288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002044003,"about_ca_topic_score_gemma":0.0005124555,"domain_scores_codex":[0.9999267,0.00001203879,0.000004868001,0.00001498675,0.00002459802,0.00001684442],"domain_scores_gemma":[0.9999686,0.000003476254,0.0000113036,0.000003164776,0.000003049497,0.00001028427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008116327,0.00002529502,0.00008466691,0.00002144374,0.00000551787,0.00002539055,0.000002351087,0.00009293823,0.9981627,0.00008672335,0.000051401,0.001360503],"study_design_scores_gemma":[0.0000318095,0.0002355962,0.001500577,0.000003257038,0.0000164729,0.0001692634,0.000005021262,0.001347883,0.9925613,0.00005456419,0.004072245,0.00000202229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824989,0.006627059,0.006461111,0.0002627435,0.00006042012,0.00004097441,0.00035246,0.0003175797,0.003378743],"genre_scores_gemma":[0.9914424,0.001749126,0.002821818,0.00006488594,0.00001205441,0.00002630997,0.0004048824,0.00002579331,0.003452794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001131773,"threshold_uncertainty_score":0.003786147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008986655396674115,"score_gpt":0.2402846630363656,"score_spread":0.2312980076396914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}