{"id":"W3168185523","doi":"10.3389/fimmu.2021.679613","title":"Autoantibody Discovery, Assay Development and Adoption: Death Valley, the Sea of Survival and Beyond","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Autoantibody; Medicine; Immunology; Systemic lupus erythematosus; Disease; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1097055,0.001346549,0.00237502,0.00337396,0.002783852,0.01873535,0.00419466,0.01080986,0.003509463],"category_scores_gemma":[0.08418458,0.001217352,0.00143732,0.002228062,0.02062773,0.02939347,0.009492638,0.01835548,0.002906409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008308609,"about_ca_system_score_gemma":0.02117631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002570526,"about_ca_topic_score_gemma":0.002324762,"domain_scores_codex":[0.9396242,0.02423849,0.003438846,0.006048492,0.02376074,0.002889184],"domain_scores_gemma":[0.9098608,0.04637427,0.004942894,0.006400851,0.02554521,0.00687603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003191923,0.0002124331,0.003220466,0.003472893,0.0001131873,0.0006739147,0.004584696,0.000769245,0.004983209,0.2881378,0.1445899,0.5489231],"study_design_scores_gemma":[0.00005208575,0.0006175558,0.0009265462,0.00281236,0.00004715974,0.001001572,0.001727739,0.0008471765,0.003424356,0.1494858,0.838913,0.000144705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007935404,0.5106648,0.03982594,0.3995338,0.01732052,0.0001954548,0.000236222,0.0009668618,0.02332096],"genre_scores_gemma":[0.1410432,0.5164075,0.07270985,0.2232469,0.0200181,0.0004345463,0.0005778502,0.001423882,0.02413825],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1097055,"threshold_uncertainty_score":0.5801852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0379425096388377,"score_gpt":0.3246970171595946,"score_spread":0.2867545075207569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}