{"id":"W3168198103","doi":"10.15252/emmm.202013591","title":"Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cachexia; Wasting; AMPK; Muscle atrophy; Wasting Syndrome; PI3K/AKT/mTOR pathway; Inflammation; Endocrinology; Autophagy; Internal medicine; Biology; Medicine; Cancer research; Skeletal muscle; Phosphorylation; Cancer; Biochemistry; Apoptosis; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904555,0.0001841808,0.0003196613,0.00004680155,0.00006144326,0.000003397943,0.00007886056,0.0002178808,0.0001570483],"category_scores_gemma":[0.001357385,0.0001513308,0.00006543953,0.0002119534,0.0001274305,0.000004199738,0.0001350003,0.0001411469,0.000002348336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007785196,"about_ca_system_score_gemma":0.00009487889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007509476,"about_ca_topic_score_gemma":0.000007184216,"domain_scores_codex":[0.9985667,0.0002998101,0.0003097206,0.0003931864,0.0001738864,0.0002567214],"domain_scores_gemma":[0.9993621,0.00005145984,0.0001531385,0.0001536151,0.000154432,0.0001253199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008335699,0.0001490054,0.0003786887,0.00005560587,0.0001410128,0.00008306857,0.00006799882,0.00004543536,0.9981757,0.0000453937,0.0002632393,0.0005114572],"study_design_scores_gemma":[0.003706922,0.0005064572,0.04892557,0.0001120102,0.0002685122,0.00002373438,0.0001268464,0.0002585685,0.9450653,0.000222547,0.0005456685,0.0002379079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897032,0.008838582,0.0005445103,0.0002010143,0.0001289117,0.0002128785,0.00001442131,0.00001577337,0.0003407592],"genre_scores_gemma":[0.9973649,0.000761016,0.0001480284,0.001160619,0.00009639244,0.00002498135,0.0003463741,0.00001982459,0.00007790305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05311049,"threshold_uncertainty_score":0.6171092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506948758018382,"score_gpt":0.2750988751167927,"score_spread":0.2600293875366088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}