{"id":"W3168198103","doi":"10.15252/emmm.202013591","title":"Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cachexia; Wasting; AMPK; Muscle atrophy; Wasting Syndrome; PI3K/AKT/mTOR pathway; Inflammation; Endocrinology; Autophagy; Internal medicine; Biology; Medicine; Cancer research; Skeletal muscle; Phosphorylation; Cancer; Biochemistry; Apoptosis; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481037,0.0004033616,0.0003521063,0.0002608867,0.000121223,0.0001979143,0.0002753159,0.000256179,0.0009190917],"category_scores_gemma":[0.00009127414,0.0001251001,0.0002576009,0.0001418469,0.0003856667,0.0001343107,0.0001727416,0.0005717877,0.0002178745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001589498,"about_ca_system_score_gemma":0.0002732458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002779674,"about_ca_topic_score_gemma":0.0005748012,"domain_scores_codex":[0.9999053,0.00001843651,0.00001174797,0.00001789431,0.00001952874,0.00002691665],"domain_scores_gemma":[0.9998844,0.00001118741,0.0000466459,0.00001129097,0.000009853897,0.00003669283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007114863,0.0001383671,0.0002031206,0.00008280067,0.00001471657,0.00006184256,0.00001058341,0.0001370643,0.9960589,0.0001469622,0.00005670897,0.002377469],"study_design_scores_gemma":[0.0001191272,0.002004136,0.004572526,0.00001965633,0.00004330829,0.000236009,0.00004914783,0.0009925924,0.9897535,0.000118199,0.002085584,0.000006193467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947746,0.001354541,0.002106029,0.0001691231,0.00004694578,0.00003357801,0.0003239299,0.0001535702,0.001037619],"genre_scores_gemma":[0.9942362,0.001459979,0.001661158,0.00005877225,0.00001370657,0.00005189329,0.0004619325,0.00002860414,0.00202783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009190917,"threshold_uncertainty_score":0.003074706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506948758018382,"score_gpt":0.2750988751167927,"score_spread":0.2600293875366088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}