{"id":"W3168266824","doi":"10.3390/cancers13112840","title":"A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation; University of Sharjah","keywords":"Apoptosis; Thioredoxin; In vivo; Thioredoxin reductase; Cancer research; Cell cycle; PI3K/AKT/mTOR pathway; Cell growth; Drug discovery; DNA damage; Cell cycle checkpoint; Pharmacology; Programmed cell death; Cancer; Cancer cell; Protein kinase B; Chemistry; Biology; Bioinformatics; Biochemistry; Oxidative stress; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005117755,0.00028286,0.0001674481,0.0001776762,0.00009886034,0.00009162723,0.0002290505,0.0001938032,0.002125294],"category_scores_gemma":[0.00004494479,0.00007406127,0.0001537409,0.0001510923,0.00009721325,0.0001673577,0.0001576272,0.0002911907,0.0004893125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308052,"about_ca_system_score_gemma":0.0001496193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002335156,"about_ca_topic_score_gemma":0.0004853443,"domain_scores_codex":[0.9999653,0.000004983987,0.00000200675,0.000009582637,0.000008072084,0.0000100119],"domain_scores_gemma":[0.999977,0.000002035912,0.00000748248,0.000002936557,0.00000394767,0.00000654948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002057654,0.0001198842,0.0002478774,0.0003125215,0.0000117883,0.0001977316,0.00002814491,0.0005578811,0.9830148,0.0003833972,0.0004493435,0.01447082],"study_design_scores_gemma":[0.0001376614,0.003825366,0.003890392,0.00002504339,0.00003960904,0.001042327,0.00002207864,0.001455229,0.9692808,0.0001470209,0.02011402,0.00002053162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685028,0.009090609,0.007725223,0.0004158371,0.00006845544,0.0002246851,0.001146609,0.0002510131,0.01257456],"genre_scores_gemma":[0.98251,0.005148325,0.005652412,0.0001467971,0.0000224121,0.00007437891,0.001133016,0.00001964109,0.005293015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002125294,"threshold_uncertainty_score":0.007109821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308104971400726,"score_gpt":0.3976968113736951,"score_spread":0.2668863142336225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}