{"id":"W3168266824","doi":"10.3390/cancers13112840","title":"A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation; University of Sharjah","keywords":"Apoptosis; Thioredoxin; In vivo; Thioredoxin reductase; Cancer research; Cell cycle; PI3K/AKT/mTOR pathway; Cell growth; Drug discovery; DNA damage; Cell cycle checkpoint; Pharmacology; Programmed cell death; Cancer; Cancer cell; Protein kinase B; Chemistry; Biology; Bioinformatics; Biochemistry; Oxidative stress; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001933403,0.0001930972,0.0002776962,0.00002349589,0.000271902,0.00002701935,0.0001124154,0.0001120256,0.001671056],"category_scores_gemma":[0.00003072996,0.0001911692,0.000068762,0.000177515,0.0001729198,0.0001179869,0.00009712509,0.0003444699,0.000009056582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523334,"about_ca_system_score_gemma":0.0004817008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000469798,"about_ca_topic_score_gemma":0.0003367563,"domain_scores_codex":[0.9988331,0.0001299105,0.0001860879,0.0003647452,0.0001095157,0.0003765966],"domain_scores_gemma":[0.9993489,0.0001189985,0.00009976589,0.00009852835,0.000143324,0.0001904975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093849,0.00009173435,0.01418471,0.00008311,0.0002934517,0.00008036047,0.001398886,0.0004063889,0.9719798,0.00182606,0.003306718,0.006239391],"study_design_scores_gemma":[0.002879164,0.00004352217,0.01086965,0.00003028706,0.0002384123,0.00001729454,0.002462361,0.002351482,0.6108378,0.0001079226,0.3696467,0.0005153858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589133,0.02764141,0.0003415418,0.0003594148,0.002402563,0.0001543562,0.0003250982,0.00005266362,0.009809629],"genre_scores_gemma":[0.9895603,0.006997377,0.0004673345,0.001789193,0.0003604425,0.00004448769,0.0000290353,0.00002409749,0.0007277148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.36634,"threshold_uncertainty_score":0.9992415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308104971400726,"score_gpt":0.3976968113736951,"score_spread":0.2668863142336225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}