{"id":"W3168285126","doi":"10.14814/phy2.14866","title":"Further evidence for functional recovery of AQP2 mutations associated with nephrogenic diabetes insipidus","year":2021,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"","keywords":"Nephrogenic diabetes insipidus; Aquaporin 2; Diabetes insipidus; Mutation; Water channel; Medicine; Xenopus; Internal medicine; Endocrinology; Biology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042883,0.00008881601,0.0001401464,0.00001226517,0.00004814503,0.000005592568,0.00002831383,0.0001095614,0.00004343752],"category_scores_gemma":[0.0004233691,0.00006770412,0.0001272967,0.00009355599,0.00006548695,0.0000064351,0.0000149655,0.00003658555,4.840199e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009035157,"about_ca_system_score_gemma":0.0001016064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001134257,"about_ca_topic_score_gemma":0.000008382081,"domain_scores_codex":[0.9992396,0.00003080003,0.000219045,0.0002694411,0.0001097666,0.0001313179],"domain_scores_gemma":[0.9992834,0.00005504355,0.0001706811,0.0001591051,0.0002984683,0.00003335237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008765722,0.0001016917,0.008603089,0.00001385408,0.0001036712,0.000006973388,0.00001016419,0.001333903,0.9891093,0.00001800113,0.000248479,0.0003632498],"study_design_scores_gemma":[0.0002831564,0.000582029,0.4331682,0.00006611558,0.00007226774,0.0000129066,0.0000416383,0.00007553295,0.5623806,0.002665328,0.0004793819,0.0001728101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977964,0.0004248409,0.001401981,0.00007487988,0.0001031258,0.0001265549,0.0000120025,0.00001063994,0.0000496214],"genre_scores_gemma":[0.9981596,0.00003146878,0.0001848701,0.0001126741,0.0001148431,0.0000568064,0.001097326,0.000008965949,0.0002334558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4267286,"threshold_uncertainty_score":0.2760894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04495297726251091,"score_gpt":0.2637122476082834,"score_spread":0.2187592703457725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}