{"id":"W3168285126","doi":"10.14814/phy2.14866","title":"Further evidence for functional recovery of AQP2 mutations associated with nephrogenic diabetes insipidus","year":2021,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"","keywords":"Nephrogenic diabetes insipidus; Aquaporin 2; Diabetes insipidus; Mutation; Water channel; Medicine; Xenopus; Internal medicine; Endocrinology; Biology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667109,0.000444308,0.0002209646,0.000601136,0.0002405481,0.0002053843,0.00027562,0.0005355495,0.002561434],"category_scores_gemma":[0.0005810194,0.00008051329,0.0003057101,0.0002564066,0.000530181,0.0001955085,0.0002806342,0.0004774666,0.0003207059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001076454,"about_ca_system_score_gemma":0.0001670819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007308351,"about_ca_topic_score_gemma":0.0003624499,"domain_scores_codex":[0.9997966,0.0000205837,0.0000284377,0.00005459806,0.00006207475,0.00003767042],"domain_scores_gemma":[0.9995463,0.0001462502,0.00009828706,0.00003988254,0.00005746352,0.0001117301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003229179,0.0000423182,0.009049044,0.0001138096,0.00004342362,0.022327,0.00015869,0.00008875483,0.9630123,0.0002516369,0.0001435582,0.004446528],"study_design_scores_gemma":[0.00005899121,0.0007995745,0.2132981,0.00004007817,0.0002134332,0.2714854,0.0005156222,0.001514325,0.503234,0.0007181818,0.008066035,0.00005639071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943069,0.000791541,0.002242859,0.0001946686,0.00004560115,0.00001347377,0.0003753005,0.00007781178,0.001951914],"genre_scores_gemma":[0.9978952,0.0004207584,0.0007729491,0.00005983611,0.00002045142,0.000005955644,0.0002426454,0.00002845248,0.0005537027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002561434,"threshold_uncertainty_score":0.008568823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04495297726251091,"score_gpt":0.2637122476082834,"score_spread":0.2187592703457725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}