{"id":"W3168334980","doi":"10.1101/2021.06.14.448335","title":"Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"","keywords":"Cell biology; Mitosis; Astral microtubules; Metaphase; Microtubule; Interphase; RHOA; Nocodazole; Biology; Cytoskeleton; Cell cycle; Moesin; Cell division; Cell; Spindle apparatus; Ezrin; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005579626,0.0003351149,0.0001765706,0.0001978374,0.0001989922,0.0002808304,0.0001250101,0.0002632732,0.001749266],"category_scores_gemma":[0.00009364913,0.0001405873,0.0001116329,0.00007908644,0.0001235231,0.0001496832,0.0001457707,0.0004407747,0.0007043899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130071,"about_ca_system_score_gemma":0.0001031674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002412912,"about_ca_topic_score_gemma":0.0005591745,"domain_scores_codex":[0.9999139,0.000008343838,0.000006061935,0.00001851419,0.00003122264,0.00002187446],"domain_scores_gemma":[0.9999191,0.00001546856,0.00003106079,0.000005637714,0.000006366654,0.00002240599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006046734,0.000009043719,0.0001182576,0.0000224416,0.000001102216,0.00004674002,0.000003824578,0.00004371824,0.9987758,0.00004499507,0.00004578933,0.0008278052],"study_design_scores_gemma":[0.00001018992,0.0001346288,0.005726841,0.000005453412,0.00000465941,0.0001500064,0.00001685178,0.000772405,0.991713,0.00003649077,0.001426834,0.00000268588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907418,0.002973299,0.002731848,0.0001823821,0.000059116,0.00002733936,0.0004098466,0.0001919352,0.002682355],"genre_scores_gemma":[0.9917836,0.001256723,0.002167663,0.0001084379,0.00003121196,0.00002661989,0.0005492168,0.0000239025,0.004052555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749266,"threshold_uncertainty_score":0.005851924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009697883758405213,"score_gpt":0.2178218100829904,"score_spread":0.2081239263245852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}