{"id":"W3168349267","doi":"10.1242/dev.199492","title":"Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; University of British Columbia; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Compute Canada; Genome Canada; Uehara Memorial Foundation; Faculty of Medicine, McGill University","keywords":"Biology; Retrotransposon; DNA methylation; Genetics; Evolutionary biology; Transposable element; Genome; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281762,0.0000925471,0.0001699178,0.00004901122,0.0001167656,0.00001939508,0.0000426778,0.00003801362,0.00001795844],"category_scores_gemma":[0.0007686559,0.00008532002,0.00002317119,0.0002763973,0.00003665461,0.00005681418,0.00007956936,0.00008613597,0.000006475573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005396949,"about_ca_system_score_gemma":0.000196819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009549891,"about_ca_topic_score_gemma":0.0003177023,"domain_scores_codex":[0.9989856,0.00002550044,0.0002751855,0.0002939316,0.0002463871,0.0001733359],"domain_scores_gemma":[0.999266,0.00007014321,0.00006013338,0.0001735393,0.0003161058,0.0001140427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001384436,0.0002340263,0.8455645,0.00007496877,0.00005433063,0.00009393906,0.008401335,0.0004871037,0.1103797,0.0004716099,0.0001142391,0.03398584],"study_design_scores_gemma":[0.0005804502,0.00008145814,0.6781662,0.00009932417,0.00002368992,0.00003954265,0.0001461629,0.00005480744,0.320394,0.00004382612,0.0002770482,0.00009345431],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718388,0.000445308,0.02604482,0.001003968,0.0001158149,0.0001581464,0.00003024999,0.00002104207,0.0003418094],"genre_scores_gemma":[0.9441175,0.000032319,0.05517843,0.0001497617,0.00006927898,0.00001951524,0.0001125434,0.000008327895,0.0003123369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2100143,"threshold_uncertainty_score":0.3479249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869468881321754,"score_gpt":0.3228468135866528,"score_spread":0.2941521247734353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}