{"id":"W3168349267","doi":"10.1242/dev.199492","title":"Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; University of British Columbia; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Compute Canada; Genome Canada; Uehara Memorial Foundation; Faculty of Medicine, McGill University","keywords":"Biology; Retrotransposon; DNA methylation; Genetics; Evolutionary biology; Transposable element; Genome; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363601,0.0003620815,0.000207117,0.00046107,0.000166009,0.0001854596,0.0002155181,0.0003285595,0.001993791],"category_scores_gemma":[0.0002584,0.0002096179,0.0002485763,0.0001367201,0.0001821732,0.00008666312,0.0002535141,0.0004279522,0.0002803793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001628191,"about_ca_system_score_gemma":0.0001624499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409288,"about_ca_topic_score_gemma":0.00195101,"domain_scores_codex":[0.9998441,0.0000209301,0.00001140951,0.00005774937,0.00004130611,0.00002440219],"domain_scores_gemma":[0.9997452,0.00004118968,0.00009256743,0.000024831,0.00002064878,0.0000755909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003292624,0.00005795234,0.01277203,0.00004025305,0.00002956886,0.001491441,0.000131003,0.00005766769,0.9788814,0.000129995,0.0001309745,0.005948459],"study_design_scores_gemma":[0.00004587899,0.001642584,0.4736766,0.00004431505,0.0001338372,0.02787793,0.0002499507,0.001091788,0.4886972,0.0002488252,0.006257727,0.00003336275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964205,0.0007552235,0.001435967,0.00004700929,0.0000135148,0.00001443351,0.0003935182,0.0000685753,0.0008512031],"genre_scores_gemma":[0.9941964,0.0005848478,0.0007812676,0.00006216302,0.000007726031,0.00001664314,0.0004472492,0.00003197389,0.003871687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001993791,"threshold_uncertainty_score":0.006669939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869468881321754,"score_gpt":0.3228468135866528,"score_spread":0.2941521247734353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}