{"id":"W3168412060","doi":"10.1200/jco.2021.39.15_suppl.11504","title":"SPEARHEAD-1: A phase 2 trial of afamitresgene autoleucel (Formerly ADP-A2M4) in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Synovial sarcoma; Tolerability; Internal medicine; Sarcoma; Progressive disease; Phases of clinical research; Leukapheresis; Surgery; Clinical endpoint; Response Evaluation Criteria in Solid Tumors; Chemotherapy; Oncology; Gastroenterology; Clinical trial; Pathology; Adverse effect; Stem cell; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001175791,0.0009448207,0.0008269709,0.0003522503,0.0002302003,0.0005497144,0.0006446074,0.0009556144,0.006931292],"category_scores_gemma":[0.0005378564,0.0002858718,0.0007955225,0.0002618191,0.0005518713,0.0006002972,0.0003402958,0.001966625,0.001076309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000528686,"about_ca_system_score_gemma":0.0008242276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004738773,"about_ca_topic_score_gemma":0.001560867,"domain_scores_codex":[0.9996933,0.000149025,0.00001568139,0.00004688587,0.00003364699,0.00006146749],"domain_scores_gemma":[0.999633,0.00008168886,0.00009003883,0.00002411096,0.00001591998,0.0001551346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6697754,0.03980571,0.009215882,0.001897584,0.001199704,0.0005517856,0.0003843514,0.002884173,0.07058071,0.0008545012,0.01464355,0.1882066],"study_design_scores_gemma":[0.5828626,0.3897331,0.01201187,0.0000791024,0.0004621169,0.0007775303,0.0000564515,0.001459825,0.006353905,0.000263111,0.005904256,0.00003606944],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890656,0.003466041,0.0005667743,0.0004752125,0.00009503698,0.001901938,0.001055689,0.0001372367,0.003236386],"genre_scores_gemma":[0.9854639,0.001899595,0.001621184,0.001029158,0.0001855944,0.001980836,0.003417999,0.00002465554,0.004377055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006931292,"threshold_uncertainty_score":0.02318752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1059983440655653,"score_gpt":0.484940799974122,"score_spread":0.3789424559085568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}