{"id":"W3168412060","doi":"10.1200/jco.2021.39.15_suppl.11504","title":"SPEARHEAD-1: A phase 2 trial of afamitresgene autoleucel (Formerly ADP-A2M4) in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Synovial sarcoma; Tolerability; Internal medicine; Sarcoma; Progressive disease; Phases of clinical research; Leukapheresis; Surgery; Clinical endpoint; Response Evaluation Criteria in Solid Tumors; Chemotherapy; Oncology; Gastroenterology; Clinical trial; Pathology; Adverse effect; Stem cell; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003131225,0.0002715641,0.002731799,0.0003546984,0.00003908236,0.00001716493,0.0003290192,0.0005082905,0.002016867],"category_scores_gemma":[0.002877819,0.0001833792,0.0006438753,0.0006459327,0.0003936957,0.000209927,0.0001134402,0.001927728,0.00001650599],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003884265,"about_ca_system_score_gemma":0.007338069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002719613,"about_ca_topic_score_gemma":0.0001960504,"domain_scores_codex":[0.9929148,0.001036815,0.003796777,0.0003972157,0.001287535,0.0005668756],"domain_scores_gemma":[0.9925403,0.003061406,0.001975629,0.0004978004,0.001288294,0.0006365989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6179101,0.03680768,0.01983756,0.00009462387,0.0003908097,0.003066973,0.0001627212,0.00001117386,0.006274871,0.000009360879,0.0004670857,0.314967],"study_design_scores_gemma":[0.614065,0.27537,0.06258947,0.0002825486,0.0003544164,0.0002413301,0.0003111667,0.00008295749,0.002934745,0.00006959605,0.04345336,0.0002454417],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925137,0.0003339388,0.00006242492,0.00130364,0.001215621,0.0007827143,0.00001646425,0.000009206924,0.003762339],"genre_scores_gemma":[0.9894717,0.0005464066,0.005640518,0.000640048,0.001184555,0.000009407634,0.00001805084,0.00005457798,0.00243473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3147216,"threshold_uncertainty_score":0.9988954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1059983440655653,"score_gpt":0.484940799974122,"score_spread":0.3789424559085568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}