{"id":"W3168490437","doi":"10.1200/jco.2021.39.15_suppl.tps5610","title":"SIENDO/ENGOT-EN5/GOG-3055: A randomized phase 3 trial of maintenance selinexor versus placebo after combination platinum-based chemotherapy in advanced or recurrent endometrial cancer.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Karyopharm Therapeutics","keywords":"Medicine; Internal medicine; Endometrial cancer; Taxane; Oncology; Placebo; Chemotherapy; Radiation therapy; Phases of clinical research; Refractory (planetary science); Gastroenterology; Surgery; Cancer; Breast cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001950633,0.001948306,0.002223458,0.0006484341,0.0004106892,0.0009574234,0.001239808,0.001836027,0.005851003],"category_scores_gemma":[0.001110432,0.0006328751,0.001553859,0.0003988374,0.001460122,0.001013657,0.0004175078,0.00324999,0.0009946532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009087667,"about_ca_system_score_gemma":0.001226424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261959,"about_ca_topic_score_gemma":0.003236989,"domain_scores_codex":[0.9994978,0.0002869589,0.00001954947,0.00007420965,0.00003337779,0.00008812782],"domain_scores_gemma":[0.9993032,0.0001609389,0.0001404984,0.00006221321,0.00003608854,0.0002970204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9692622,0.01324743,0.0006144952,0.0003511789,0.0004345141,0.00004646328,0.00005397864,0.0003304887,0.003937615,0.0001326991,0.0008530779,0.01073577],"study_design_scores_gemma":[0.9029722,0.09425741,0.001345731,0.00001498749,0.0001703623,0.00002775961,0.00001843278,0.0003646227,0.0003409235,0.00009596057,0.0003813875,0.00001022222],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881661,0.002449155,0.0004761404,0.0006477091,0.0003541749,0.00449941,0.00115388,0.0001832097,0.002070166],"genre_scores_gemma":[0.9837998,0.00161045,0.001607074,0.001470349,0.0003005507,0.005502328,0.001502982,0.00003368023,0.004172783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005851003,"threshold_uncertainty_score":0.01957357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06155120322114999,"score_gpt":0.4491605257135973,"score_spread":0.3876093224924473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}