{"id":"W3168498503","doi":"10.1210/clinem/dgab453","title":"Novel Anaplastic Thyroid Cancer PDXs and Cell Lines: Expanding Preclinical Models of Genetic Diversity","year":2021,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Cancer Prevention and Research Institute of Texas","keywords":"Anaplastic thyroid cancer; CDKN2A; Cancer research; Cancer; PAX8; KRAS; Thyroid cancer; HRAS; Medicine; In vivo; Anaplastic large-cell lymphoma; Cell culture; Biology; Pathology; Lymphoma; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001049895,0.0005917315,0.000367254,0.0009052149,0.0003635676,0.0006237276,0.0005852442,0.0005625187,0.001500183],"category_scores_gemma":[0.0003879019,0.0001796639,0.0005083696,0.0004313419,0.000425993,0.0005920615,0.0006265079,0.001492999,0.0006249106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005132305,"about_ca_system_score_gemma":0.0003627267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007495079,"about_ca_topic_score_gemma":0.001394446,"domain_scores_codex":[0.9994473,0.0001070417,0.00007703841,0.00008560847,0.0002221754,0.00006076075],"domain_scores_gemma":[0.9994494,0.0001556097,0.00006941057,0.0001367699,0.00009039593,0.00009825758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003561053,0.0006638597,0.002656708,0.0001751959,0.00002213177,0.0002916941,0.0002316495,0.0006480499,0.9862217,0.0008003184,0.0004750107,0.007457721],"study_design_scores_gemma":[0.0001414042,0.006119366,0.01062845,0.0000413296,0.0001238093,0.002944049,0.000199018,0.004085876,0.9582388,0.0003345382,0.0171215,0.00002173684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665518,0.002521576,0.02300343,0.0002711097,0.00008465701,0.0009667895,0.001750868,0.0002852548,0.004564473],"genre_scores_gemma":[0.9543068,0.003346751,0.02964715,0.0001498578,0.00004838617,0.001194072,0.004973404,0.00006916559,0.00626444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001500183,"threshold_uncertainty_score":0.005552411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0911806097442102,"score_gpt":0.3810994930972419,"score_spread":0.2899188833530317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}