{"id":"W3168509201","doi":"10.1101/2020.10.30.360925","title":"Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada; University of Ottawa","funders":"","keywords":"Epitope; Antigen; Chimeric antigen receptor; Receptor; In vivo; Truncation (statistics); T-cell receptor; Hinge; Cancer research; Chemistry; Biology; Cell biology; Molecular biology; Immunotherapy; Immunology; T cell; Immune system; Biochemistry; Computer science; Genetics; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002621726,0.0002503557,0.0001658138,0.0001130534,0.0000665258,0.0001984889,0.0002063174,0.0002196954,0.00078848],"category_scores_gemma":[0.0002352746,0.00009558894,0.0001908124,0.00009315259,0.0001560862,0.0001470532,0.0001564607,0.0003563651,0.0001896028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000211846,"about_ca_system_score_gemma":0.0000800496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002312188,"about_ca_topic_score_gemma":0.0002055893,"domain_scores_codex":[0.9998454,0.00002606653,0.00002178883,0.00002704193,0.00003664772,0.0000430713],"domain_scores_gemma":[0.9998254,0.00006408212,0.00004481596,0.00002525983,0.00001918605,0.00002130514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004344124,0.000008337742,0.0000999005,0.000006059835,0.000002133421,0.00001185897,0.000003891702,0.00009625495,0.9995408,0.00001188516,0.000004940491,0.0001703628],"study_design_scores_gemma":[0.000003526453,0.0001387777,0.0009072717,9.010537e-7,0.000004671479,0.00007700788,0.000004217328,0.0005255454,0.998159,0.000006049415,0.0001714938,0.000001590892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983817,0.0001167178,0.001141509,0.00001060301,0.000003158136,0.000009687924,0.00007242705,0.00001705793,0.0002470518],"genre_scores_gemma":[0.9987531,0.00008501045,0.0007124942,0.00001690258,0.000001403149,0.000009596522,0.0001394194,0.000007186228,0.0002749486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00078848,"threshold_uncertainty_score":0.002637744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03233509677387081,"score_gpt":0.2715262690409532,"score_spread":0.2391911722670824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}