{"id":"W3168529792","doi":"10.3390/ph14060547","title":"Design, Synthesis, In Vitro and In Vivo Evaluation of Heterobivalent SiFAlin-Modified Peptidic Radioligands Targeting Both Integrin αvβ3 and the MC1 Receptor—Suitable for the Specific Visualization of Melanomas?","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Bundesministerium für Bildung und Forschung; Wilhelm Sander-Stiftung","keywords":"In vivo; Receptor; In vitro; Integrin; Melanocortin 1 receptor; Chemistry; Melanoma; Peptide; Cancer research; Ligand (biochemistry); Molecular biology; Biophysics; Biochemistry; Medicine; Biology; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006798455,0.0001346832,0.0004229095,0.0001472178,0.00005468045,0.00002336995,0.00009734599,0.0000753245,0.0001919894],"category_scores_gemma":[0.002252418,0.00008601384,0.00006224326,0.0003506393,0.0002299159,0.00005299362,0.00008408793,0.0002060489,7.65754e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001034239,"about_ca_system_score_gemma":0.000134983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001716976,"about_ca_topic_score_gemma":0.00000313075,"domain_scores_codex":[0.99718,0.001126537,0.0005767011,0.0002883678,0.0005692906,0.0002591067],"domain_scores_gemma":[0.9956744,0.003634525,0.000128277,0.0002078084,0.0002806076,0.0000744319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00287485,0.0001673488,0.0009517598,0.0002904195,0.00005578599,0.0000026042,0.0007185803,0.0003678186,0.9872407,0.0001765722,0.0001540239,0.006999532],"study_design_scores_gemma":[0.00460316,0.00005010034,0.00064207,0.0001721746,0.0001341064,0.000007260342,0.0005148896,0.1228445,0.8703508,0.000136767,0.0004723404,0.00007181484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680485,0.01761669,0.009802623,0.001474828,0.00008508143,0.002739375,0.00001569542,0.000009570503,0.0002076138],"genre_scores_gemma":[0.9934829,0.005218182,0.0008717536,0.00007756803,0.0000466715,0.000217357,0.00001116295,0.00002165228,0.00005274855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1224767,"threshold_uncertainty_score":0.3507543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1148630568265688,"score_gpt":0.4014161655034054,"score_spread":0.2865531086768366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}