{"id":"W3168529792","doi":"10.3390/ph14060547","title":"Design, Synthesis, In Vitro and In Vivo Evaluation of Heterobivalent SiFAlin-Modified Peptidic Radioligands Targeting Both Integrin αvβ3 and the MC1 Receptor—Suitable for the Specific Visualization of Melanomas?","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Bundesministerium für Bildung und Forschung; Wilhelm Sander-Stiftung","keywords":"In vivo; Receptor; In vitro; Integrin; Melanocortin 1 receptor; Chemistry; Melanoma; Peptide; Cancer research; Ligand (biochemistry); Molecular biology; Biophysics; Biochemistry; Medicine; Biology; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636426,0.0002990721,0.0001612294,0.00007776952,0.00007250219,0.000157589,0.0002187018,0.0003943705,0.0004485646],"category_scores_gemma":[0.0001072559,0.0001135483,0.0001629381,0.00006671086,0.0001112118,0.0001487193,0.00007614052,0.0001852243,0.0002608683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831416,"about_ca_system_score_gemma":0.00009566089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003666364,"about_ca_topic_score_gemma":0.0004623563,"domain_scores_codex":[0.9999201,0.00002008502,0.000004802463,0.00001969461,0.00001810876,0.0000172345],"domain_scores_gemma":[0.9999417,0.000007380919,0.00002554354,0.000005070896,0.000008437075,0.00001181904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049826,0.00002538843,0.00007200391,0.00004747622,0.000003780713,0.00002937261,0.00000793349,0.0002002876,0.9978715,0.00003311313,0.00001659801,0.001587375],"study_design_scores_gemma":[0.00002292991,0.0008568981,0.0006080697,0.000002576635,0.0000103015,0.0001891328,0.000007888377,0.0006570639,0.9960083,0.00001116983,0.001621571,0.000004134426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871595,0.002118548,0.009478799,0.00007903655,0.00002213275,0.0001176616,0.0001709149,0.00004239375,0.0008109529],"genre_scores_gemma":[0.9833815,0.001466291,0.01318884,0.00006413097,0.00001197788,0.00007678898,0.0003202435,0.00001305163,0.001477269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004485646,"threshold_uncertainty_score":0.002054334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1148630568265688,"score_gpt":0.4014161655034054,"score_spread":0.2865531086768366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}