{"id":"W3168549257","doi":"10.1016/j.celrep.2021.109227","title":"Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation","keywords":"Notch signaling pathway; T-cell receptor; Biology; Cell biology; T cell; Cellular differentiation; Signal transduction; Immunology; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002573063,0.0002441199,0.000299357,0.0001538174,0.0002083151,0.0000481153,0.00004806392,0.0002932161,0.01513682],"category_scores_gemma":[0.00004683707,0.0002529635,0.0001372771,0.0001619784,0.00004770112,0.0001713907,0.00006889336,0.0004140231,0.0001849386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147457,"about_ca_system_score_gemma":0.0001310254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008540543,"about_ca_topic_score_gemma":0.00003434371,"domain_scores_codex":[0.9981654,0.0002152818,0.0006199433,0.0005817725,0.00008280192,0.0003347694],"domain_scores_gemma":[0.9990448,0.0001610725,0.0003475642,0.0002672812,0.0001399421,0.0000393782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000946041,0.0004072517,0.005741569,0.00004647892,0.00003028377,0.00005495549,0.0003122818,0.00006791771,0.9812917,0.000002784969,0.01144788,0.0005023379],"study_design_scores_gemma":[0.0007349916,0.00007803559,0.00143036,0.00003976392,0.00005205205,0.0001209577,0.0003875434,0.00004236947,0.9260227,0.00001463216,0.07083051,0.0002460907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675995,0.004134994,0.0003403194,0.00004955495,0.005830816,0.0001768002,0.000003833936,0.00007338171,0.02179087],"genre_scores_gemma":[0.9075943,0.0002092293,0.0000730176,0.0001010077,0.00007534261,0.00002032395,0.0003455637,0.00002580126,0.09155536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06976449,"threshold_uncertainty_score":0.9999923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225300908772658,"score_gpt":0.2079329337303786,"score_spread":0.195679924642652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}