{"id":"W3168598724","doi":"10.1200/jco.2021.39.15_suppl.4135","title":"Predictive value of germline <i>ATM</i> mutations in the CCTG PA.7 trial: Gemcitabine (GEM) and nab-paclitaxel (Nab-P) versus GEM, nab-P, durvalumab (D) and tremelimumab (T) as first-line therapy in metastatic pancreatic ductal adenocarcinoma (mPDAC).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Genome British Columbia; Sunnybrook Health Science Centre; Centre Hospitalier Universitaire de Sherbrooke; Cancer Care Ontario; Centre hospitalier universitaire de Québec; BC Cancer Agency; Vancouver General Hospital; University of Calgary; Princess Margaret Cancer Centre; Health Sciences Centre; University Health Network; Ottawa Hospital; Centre Hospitalier de l’Université de Montréal; McGill University; Moncton Hospital","funders":"","keywords":"Medicine; Internal medicine; Germline; Gemcitabine; Clinical endpoint; Oncology; Surrogate endpoint; Gastroenterology; Urology; Randomized controlled trial; Cancer; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001646943,0.0007235666,0.001419302,0.0002616262,0.000194106,0.0007210888,0.0005033855,0.001014377,0.002048198],"category_scores_gemma":[0.002179663,0.0003382945,0.001148913,0.0002908231,0.0005230857,0.0005234807,0.000282888,0.002406146,0.0003389573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000757521,"about_ca_system_score_gemma":0.0009880295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011151,"about_ca_topic_score_gemma":0.00260236,"domain_scores_codex":[0.9992641,0.0005264959,0.00003046722,0.0000761238,0.00004778963,0.00005504268],"domain_scores_gemma":[0.9983844,0.0007000628,0.0004017852,0.00008080074,0.00008392962,0.0003491076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9470847,0.002881165,0.009846689,0.0004466363,0.001261814,0.00006967757,0.00006496429,0.00133055,0.005601122,0.000126868,0.002130678,0.02915516],"study_design_scores_gemma":[0.6593401,0.2711646,0.05192235,0.0001779931,0.004535097,0.0004514498,0.00006744726,0.006648783,0.002517637,0.0004819289,0.002634667,0.00005789418],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959584,0.001759349,0.0001226697,0.0003953126,0.00006818395,0.0002490612,0.0003693629,0.00002847327,0.001049156],"genre_scores_gemma":[0.9965966,0.0006268783,0.0004132688,0.000319445,0.0001501703,0.00031864,0.000924322,0.00001229191,0.0006383228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002048198,"threshold_uncertainty_score":0.008709908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648503272818469,"score_gpt":0.477133248956377,"score_spread":0.3122829216745301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}