{"id":"W3168604442","doi":"10.15252/emmm.201708253","title":"Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer","year":2021,"lang":"en","type":"review","venue":"EMBO Molecular Medicine","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Worldwide Cancer Research; University of Toronto; Canadian Cancer Society","keywords":"Medicine; Angiopoietin receptor; Angiogenesis; Cancer; Metastasis; Adjuvant; Bevacizumab; Cancer research; Oncology; Pharmacology; Immunology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003820726,0.0006772788,0.0009051437,0.001361368,0.0001784123,0.0006458539,0.0006055537,0.0007156136,0.00281971],"category_scores_gemma":[0.0003763732,0.0001831117,0.0004262418,0.00110828,0.0002728577,0.0009409685,0.0004281931,0.001926526,0.001479267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003329767,"about_ca_system_score_gemma":0.0005145555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574387,"about_ca_topic_score_gemma":0.001008758,"domain_scores_codex":[0.9998994,0.0000195527,0.00001288989,0.00001580415,0.00004057511,0.00001189291],"domain_scores_gemma":[0.9998603,0.00007085703,0.00001984122,0.000003882246,0.00002965499,0.0000154819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001156723,0.00009920989,0.00009527565,0.01078007,0.00007002016,0.0001808364,0.00003985848,0.0003622236,0.002794943,0.002774108,0.0214489,0.9612389],"study_design_scores_gemma":[0.00004733761,0.0002476267,0.0007867013,0.003079417,0.0001332508,0.001365577,0.00004061674,0.0001438536,0.0008771957,0.002089386,0.9911708,0.00001825304],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001648558,0.9983289,0.0001343561,0.0002111306,0.0002336457,0.000005825829,0.00001547849,0.000007121963,0.0008987165],"genre_scores_gemma":[0.00070488,0.9981946,0.000183126,0.0001847116,0.0001563905,0.000008105567,0.00002774422,0.000001503024,0.0005389358],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00281971,"threshold_uncertainty_score":0.009432912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03264019639431618,"score_gpt":0.3549727057049447,"score_spread":0.3223325093106285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}