{"id":"W3168754484","doi":"10.3389/fcell.2021.673395","title":"“Janus-Faced” α-Synuclein: Role in Parkinson’s Disease","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"College of Pharmacy and Nutrition, University of Saskatchewan; Indian Council of Medical Research; JSS Academy of Higher Education and Research","keywords":"Parkinson's disease; Lewy body; Neurite; Protein aggregation; Autophagy; Pathological; Neuroscience; Alpha-synuclein; Cell biology; Amyloid (mycology); Biology; Disease; Chemistry; Pathology; Medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169212,0.0004824329,0.0007267877,0.0007304035,0.0002555643,0.0009690062,0.0003838068,0.000647767,0.00109353],"category_scores_gemma":[0.0001589984,0.0001244505,0.0002001978,0.001097259,0.0003336606,0.0007376184,0.0004595095,0.0007195114,0.001040404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003240244,"about_ca_system_score_gemma":0.0004714343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000287174,"about_ca_topic_score_gemma":0.0004834346,"domain_scores_codex":[0.9999104,0.000012997,0.00001245533,0.00002472073,0.00002770979,0.00001187487],"domain_scores_gemma":[0.999915,0.0000208737,0.00002193867,0.000002099403,0.00002366719,0.00001630981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003370523,0.00008375001,0.0009317748,0.0277587,0.0001246331,0.001791744,0.0004910919,0.00065185,0.05243544,0.01120301,0.03654328,0.8676477],"study_design_scores_gemma":[0.0000155082,0.0002323465,0.003436261,0.002109618,0.0001279588,0.004364054,0.000207493,0.000160454,0.003897308,0.005019538,0.9804044,0.00002503071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009302419,0.9972383,0.0002108145,0.0002533405,0.0003362093,0.000002968052,0.00002495871,0.00001085474,0.0009923078],"genre_scores_gemma":[0.005282833,0.9926231,0.0002816891,0.0001519041,0.0004709539,0.000004743317,0.0000584264,0.000002657326,0.001123701],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00109353,"threshold_uncertainty_score":0.003658235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02009706791260538,"score_gpt":0.2705400370160408,"score_spread":0.2504429691034354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}