{"id":"W3168883143","doi":"10.1101/2021.05.31.445492","title":"A Family of Glycosylated Macrolides Selectively Target Energetic Vulnerabilities in Leukemia","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Mutagenesis; ATP synthase; CRISPR; Biology; In vivo; Leukemia; Mechanism of action; Mutation; Cancer research; Biochemistry; Cell biology; Chemistry; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000565321,0.000508262,0.0006806419,0.000253042,0.00007571099,0.00009142968,0.0005592606,0.0007693803,0.00004741743],"category_scores_gemma":[0.0005372936,0.0005621159,0.0002397404,0.0005007172,0.0002238304,0.00001151599,0.0007815087,0.0006979316,0.000005320389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000277086,"about_ca_system_score_gemma":0.002418816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000488075,"about_ca_topic_score_gemma":0.00002811418,"domain_scores_codex":[0.9968176,0.0003671854,0.0006498118,0.001115923,0.0003898182,0.0006596097],"domain_scores_gemma":[0.9977244,0.00005176157,0.0002657356,0.001069761,0.0007027192,0.0001856663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001202413,0.0001456138,0.01308591,0.0004067202,0.0001891135,0.00007579012,0.00001131577,0.0009514184,0.9848408,0.00003330706,0.0001371724,0.000002592252],"study_design_scores_gemma":[0.0005299757,0.0001372803,0.03920638,0.0002782015,0.00003046814,1.918171e-8,0.00002230191,0.0004908788,0.9576653,0.000002576227,0.001087942,0.0005487188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926779,0.005674121,0.0006633849,0.00003418602,0.0002327556,0.0004114265,0.0002351877,0.00004404596,0.00002700354],"genre_scores_gemma":[0.9955975,0.001109314,0.002651277,0.0000839706,0.0002338995,0.0001856093,0.000005717149,0.0001133906,0.00001929563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02717556,"threshold_uncertainty_score":0.999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141694106195541,"score_gpt":0.2395875491366169,"score_spread":0.2281706080746615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}