{"id":"W3168883143","doi":"10.1101/2021.05.31.445492","title":"A Family of Glycosylated Macrolides Selectively Target Energetic Vulnerabilities in Leukemia","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Mutagenesis; ATP synthase; CRISPR; Biology; In vivo; Leukemia; Mechanism of action; Mutation; Cancer research; Biochemistry; Cell biology; Chemistry; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007707765,0.0001891481,0.0001239441,0.00011921,0.00009047992,0.0001932579,0.0001054321,0.0001661992,0.0006944315],"category_scores_gemma":[0.00006270667,0.00005681779,0.00008804807,0.00008995761,0.0001067432,0.00009882066,0.0001644018,0.0002880805,0.0002054636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120842,"about_ca_system_score_gemma":0.00008121997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002335592,"about_ca_topic_score_gemma":0.0003413025,"domain_scores_codex":[0.9999677,0.000004895119,0.000002678636,0.000008632841,0.000007886309,0.00000826832],"domain_scores_gemma":[0.9999647,0.00000422607,0.00001038248,0.000004522221,0.000004383923,0.00001174865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132475,0.00001417746,0.0003215996,0.00001175638,0.000003293099,0.00005339835,0.000006125693,0.0001617422,0.9960432,0.0001244598,0.00006962818,0.003077381],"study_design_scores_gemma":[0.00002998195,0.0005379035,0.004544055,0.000004118246,0.0000121157,0.0005687427,0.00001360544,0.0008773626,0.9870388,0.00008520628,0.006283769,0.000004278093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946583,0.001095491,0.002247262,0.00009011268,0.00001580731,0.00002848238,0.0002600749,0.00007138678,0.001533187],"genre_scores_gemma":[0.9956715,0.0006557886,0.001921256,0.00007225166,0.000005104883,0.00002101985,0.0002556,0.00001243306,0.001385017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006944315,"threshold_uncertainty_score":0.002323091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141694106195541,"score_gpt":0.2395875491366169,"score_spread":0.2281706080746615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}