{"id":"W3168973386","doi":"10.1016/j.jaci.2021.04.039","title":"Therapeutic options for CTLA-4 insufficiency","year":2021,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Università degli Studi di Brescia; Universitat de Barcelona; Medizinischen Hochschule Hannover; Ministerstvo Zdravotnictví Ceské Republiky; Else Kröner-Fresenius-Stiftung; Bundesministerium für Bildung und Forschung; University of Bern; Deutsche Forschungsgemeinschaft; Inselspital, Universitätsspital Bern; Universität Zürich; Johns Hopkins University","keywords":"CTLA-4; Medicine; Intensive care medicine; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002746714,0.0003910763,0.000544721,0.0003931363,0.0003330298,0.0004504356,0.0003337433,0.0006790303,0.004487362],"category_scores_gemma":[0.0002850952,0.00007551663,0.0005565889,0.0001664684,0.0002894339,0.0002805978,0.0003900855,0.001665415,0.0007892791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873698,"about_ca_system_score_gemma":0.0002236001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001092324,"about_ca_topic_score_gemma":0.0001310263,"domain_scores_codex":[0.9999262,0.00001655742,0.000005647155,0.00000839504,0.00001348754,0.00002976351],"domain_scores_gemma":[0.9999341,0.00002871533,0.00001125011,0.000004384002,0.000004618275,0.00001701983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006496562,0.0008613887,0.004826373,0.001739293,0.0003755213,0.02318783,0.0001532223,0.002777213,0.04368494,0.02191683,0.02284162,0.8711392],"study_design_scores_gemma":[0.008819154,0.01067932,0.01646339,0.002346766,0.001022304,0.1203116,0.0003540489,0.006414676,0.0407644,0.05066148,0.7420576,0.000105388],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2860838,0.5570884,0.02633947,0.03062632,0.003569296,0.000311495,0.0004656187,0.0007573655,0.09475826],"genre_scores_gemma":[0.9006841,0.07221889,0.006507689,0.005527299,0.001783712,0.0002987437,0.0005151348,0.00004821042,0.01241618],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004487362,"threshold_uncertainty_score":0.01501173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02848610487601592,"score_gpt":0.31720213930772,"score_spread":0.288716034431704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}