{"id":"W3168973386","doi":"10.1016/j.jaci.2021.04.039","title":"Therapeutic options for CTLA-4 insufficiency","year":2021,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Università degli Studi di Brescia; Universitat de Barcelona; Medizinischen Hochschule Hannover; Ministerstvo Zdravotnictví Ceské Republiky; Else Kröner-Fresenius-Stiftung; Bundesministerium für Bildung und Forschung; University of Bern; Deutsche Forschungsgemeinschaft; Inselspital, Universitätsspital Bern; Universität Zürich; Johns Hopkins University","keywords":"CTLA-4; Medicine; Intensive care medicine; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007171386,0.0001475171,0.0004819572,0.00009015541,0.0002403658,0.00001839304,0.0002717072,0.0004051518,0.0004910911],"category_scores_gemma":[0.0005497278,0.0001228723,0.0003825655,0.0001397854,0.0005894778,0.00012171,0.00008545879,0.0005972491,0.00003088537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001199688,"about_ca_system_score_gemma":0.0002638677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004932986,"about_ca_topic_score_gemma":0.000004369725,"domain_scores_codex":[0.9980659,0.0003539201,0.001014036,0.0002090284,0.00003391901,0.0003231771],"domain_scores_gemma":[0.9981822,0.0007423382,0.0004405089,0.0002245201,0.0003983538,0.00001203527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002857863,0.008486781,0.001065591,0.00003365862,0.01272782,0.00008362421,0.00118959,0.00007003111,0.4166387,0.1129833,0.002712328,0.4411507],"study_design_scores_gemma":[0.01001443,0.004970434,0.06211545,0.0000936774,0.0003547522,0.001825058,0.003248695,0.00002470017,0.0154491,0.007676883,0.8937601,0.0004666754],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6210526,0.36515,0.004510365,0.002864214,0.004792773,0.0001210273,0.000009949786,0.00002513351,0.001473949],"genre_scores_gemma":[0.9772922,0.01988616,0.0002659453,0.0006797901,0.00002565763,0.000005112524,0.00001976796,0.00001489129,0.001810435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8910478,"threshold_uncertainty_score":0.5377104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02848610487601592,"score_gpt":0.31720213930772,"score_spread":0.288716034431704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}