{"id":"W3168980228","doi":"10.3390/cells10061530","title":"Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"T cell; Avidity; Cell biology; Biology; T-cell receptor; Immune tolerance; Antigen; Immunology; Immunotherapy; Immune system; Receptor; Peripheral tolerance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007510798,0.0002773137,0.001375382,0.00005383523,0.00008174126,0.00001090946,0.0004416847,0.0005002302,0.0001292602],"category_scores_gemma":[0.00004751569,0.0001566099,0.0002005613,0.0001847645,0.0006839461,0.00002741363,0.0002185375,0.000724773,0.00002309244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001036615,"about_ca_system_score_gemma":0.0001127598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002952553,"about_ca_topic_score_gemma":0.00009002273,"domain_scores_codex":[0.9970809,0.001611639,0.000692026,0.0003285568,0.00003966974,0.0002472643],"domain_scores_gemma":[0.9973885,0.001471446,0.0005267817,0.0005608526,0.00004236767,0.00001000447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006000803,0.001282699,0.0002415545,0.01165614,0.0005062363,0.00001162805,0.004062191,5.228152e-7,0.2903038,0.002018773,0.001285045,0.6885714],"study_design_scores_gemma":[0.0004354033,0.00006622545,0.00003749743,0.0009275401,0.0002268444,0.00003082312,0.001052125,1.048731e-7,0.03737145,0.0001015684,0.9595647,0.0001856877],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03943066,0.9572151,3.71314e-7,0.00001812767,0.0002490847,0.0003620041,0.0001088117,0.000005641879,0.00261025],"genre_scores_gemma":[0.06982154,0.9294286,0.00001349365,0.0000267365,0.0000180098,0.00001885727,0.00006418247,0.0000124093,0.0005961467],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9582797,"threshold_uncertainty_score":0.6386367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03009117251093226,"score_gpt":0.2854720023070147,"score_spread":0.2553808297960825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}