{"id":"W3168980228","doi":"10.3390/cells10061530","title":"Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"T cell; Avidity; Cell biology; Biology; T-cell receptor; Immune tolerance; Antigen; Immunology; Immunotherapy; Immune system; Receptor; Peripheral tolerance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009854964,0.001228765,0.001994267,0.002087998,0.0004021379,0.002109129,0.001589501,0.002056984,0.002179119],"category_scores_gemma":[0.001187891,0.0004186436,0.0004008087,0.00227431,0.00230047,0.003801719,0.001079487,0.003884288,0.002745797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001512773,"about_ca_system_score_gemma":0.001125815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009558485,"about_ca_topic_score_gemma":0.000976036,"domain_scores_codex":[0.9995703,0.00008969082,0.00005077095,0.00007824927,0.0001731705,0.00003789102],"domain_scores_gemma":[0.9995075,0.0002629015,0.00005004011,0.00001725136,0.0001139587,0.00004835353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001480988,0.00004995919,0.0002153563,0.01201242,0.00006352904,0.0002873193,0.0001529779,0.0004049299,0.003978095,0.02031237,0.0689282,0.8934468],"study_design_scores_gemma":[0.000009489672,0.00005657559,0.0004843496,0.001840748,0.00003120637,0.0009846275,0.000064457,0.00006075704,0.0003769259,0.006480248,0.989592,0.00001867406],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006350115,0.9975987,0.0001387043,0.0005357636,0.0007023462,0.00000211646,0.000006511335,0.000005324807,0.0009470264],"genre_scores_gemma":[0.0007503053,0.9964101,0.0001943971,0.0006703789,0.0007659919,0.000006476096,0.00001532954,0.000003716038,0.001183306],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002179119,"threshold_uncertainty_score":0.01097596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03009117251093226,"score_gpt":0.2854720023070147,"score_spread":0.2553808297960825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}