{"id":"W3169027651","doi":"10.3791/62672","title":"Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry","year":2021,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Hydrogen–deuterium exchange; Chemistry; Mass spectrometry; Electrospray ionization; Deuterium; Elution; Capillary electrophoresis; Analytical Chemistry (journal); Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001496331,0.000194153,0.0004151079,0.0002578138,0.00008413802,0.00004539934,0.0002083201,0.0001082298,0.002374069],"category_scores_gemma":[0.00002780841,0.0001709218,0.0001799589,0.0004570763,0.00004113767,0.0001756026,0.00002410928,0.0001394377,0.000001237576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001646889,"about_ca_system_score_gemma":0.0002733063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002004407,"about_ca_topic_score_gemma":1.662254e-7,"domain_scores_codex":[0.9983792,0.00002366142,0.0006823306,0.0001750778,0.0004913789,0.0002483294],"domain_scores_gemma":[0.9981233,0.00003077514,0.0009078024,0.0002528585,0.0005758897,0.0001093447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003975715,0.0003847737,0.0004312972,0.000203721,0.0001508208,0.0000107918,0.00008353568,0.000002230102,0.9970117,0.001124717,0.00008411743,0.0001147005],"study_design_scores_gemma":[0.002081284,0.0003660704,0.0001006192,0.0001356652,0.00005231388,0.00006061522,0.00009366534,0.0002428894,0.9906724,0.000255624,0.005760815,0.0001780462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9345724,0.0004796522,0.06291158,0.0002894035,0.0000388419,0.0003151985,0.0001076827,0.0000360334,0.001249187],"genre_scores_gemma":[0.9445045,0.0001526682,0.0542238,0.0001082913,0.0002161009,0.0001702013,0.0002789053,0.00004229184,0.0003032666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009932061,"threshold_uncertainty_score":0.9985379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517463200558564,"score_gpt":0.338627690016177,"score_spread":0.3234530580105913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}