{"id":"W3169109481","doi":"10.1001/jamacardio.2021.1627","title":"Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals","year":2021,"lang":"en","type":"article","venue":"JAMA Cardiology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"Economic and Social Research Council; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust; World Health Organization","keywords":"Genome-wide association study; Medicine; Odds ratio; Heart disease; Locus (genetics); Genetics; Proband; Single-nucleotide polymorphism; Internal medicine; Genotype; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227214,0.00007566545,0.0003815562,0.00007682043,0.00001490113,0.000005390507,0.00001770879,0.0000805354,0.00004707893],"category_scores_gemma":[0.0003320069,0.00005957443,0.00007686731,0.0002536835,0.00004441887,0.00002948776,0.00001968348,0.0001029798,0.00001375316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386189,"about_ca_system_score_gemma":0.0001371943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00011018,"about_ca_topic_score_gemma":0.000025206,"domain_scores_codex":[0.9993198,0.00008010816,0.0001782102,0.0001584592,0.0001155323,0.0001478882],"domain_scores_gemma":[0.9994016,0.0001534123,0.00007353199,0.0001806391,0.0001179958,0.00007282904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005130103,0.0002123125,0.9978453,0.00003368055,0.0003144934,0.00005967525,0.00008456579,0.0002707711,0.0002577896,0.00009067057,0.000458172,0.0003212511],"study_design_scores_gemma":[0.003168426,0.000169825,0.9948613,0.00008314789,0.0001945744,0.00003993146,0.0001098336,0.00004681637,0.000187535,0.00007850761,0.001007587,0.00005248999],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994305,0.00009371534,0.0001356562,0.002041215,0.00004970828,0.0002253735,0.0000392931,0.00001358922,0.003096446],"genre_scores_gemma":[0.9990367,0.00001878748,0.0002957107,0.0001447056,0.00004355834,0.0000450056,0.00005249365,0.000007817589,0.0003552233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004731694,"threshold_uncertainty_score":0.2429375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659971516087317,"score_gpt":0.2742313692756048,"score_spread":0.2576316541147317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}