{"id":"W3169149480","doi":"10.1096/fasebj.2021.35.s1.01886","title":"mTORC1 Activity Occurs Predominantly in the Periphery of Human Skeletal Muscle Fibers Following Anabolic Stimuli","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"mTORC1; Anabolism; P70-S6 Kinase 1; Skeletal muscle; Internal medicine; Endocrinology; Kinase; Phosphorylation; Chemistry; Biology; Cell biology; Medicine; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001970957,0.0001659696,0.0004943317,0.00009050527,0.0002298711,0.00005570871,0.0002653509,0.00007130329,0.00006747626],"category_scores_gemma":[0.0003446365,0.000100429,0.0009103085,0.0003524011,0.0001271861,0.0001492224,0.00007448636,0.0007097745,0.000005925497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001057577,"about_ca_system_score_gemma":0.0002176001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008040101,"about_ca_topic_score_gemma":0.00003820567,"domain_scores_codex":[0.9979714,0.0005880261,0.0002782116,0.0001820418,0.0006598205,0.000320479],"domain_scores_gemma":[0.9988335,0.0002293926,0.0001323282,0.000622929,0.00008184982,0.000100045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002716158,0.0005915759,0.009737787,0.0001338885,0.000847458,0.005204406,0.006145362,0.0005883246,0.914522,0.00004336872,0.001471772,0.06044248],"study_design_scores_gemma":[0.01184581,0.0008248395,0.8087663,0.001252216,0.002309286,0.005393213,0.009334899,0.0005375644,0.1573198,0.0002658105,0.001623463,0.0005267901],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956214,0.001865469,0.00007989198,0.0005034023,0.0002710067,0.0002927821,0.000004590159,0.00001087645,0.001350547],"genre_scores_gemma":[0.999176,0.00007760796,0.00008779077,0.0001413872,0.0003418901,0.000007035037,0.000003572828,0.00002338629,0.0001413787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7990285,"threshold_uncertainty_score":0.4095378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771857631295671,"score_gpt":0.2933892745283664,"score_spread":0.2756706982154097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}