{"id":"W3169165326","doi":"10.3390/jof7060468","title":"Differential Proinflammatory Responses to Aspergillus fumigatus by Airway Epithelial Cells In Vitro Are Protease Dependent","year":2021,"lang":"en","type":"article","venue":"Journal of Fungi","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Manchester Biomedical Research Centre; Simon Fraser University; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Medical Research Council; National Institute for Health and Care Research","keywords":"Proteases; Aspergillus fumigatus; Proinflammatory cytokine; Microbiology; Biology; Protease; Cysteine protease; Cytokine; Immune system; Immunology; Inflammation; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004511841,0.0001880565,0.000571761,0.0001635673,0.00005256225,0.00003444992,0.0001289991,0.0001232049,0.000348986],"category_scores_gemma":[0.0005768728,0.0001493358,0.0002533742,0.0001933878,0.00003942017,0.0001119687,0.00005823258,0.0005449691,0.00004341254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002613891,"about_ca_system_score_gemma":0.0006369817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008785309,"about_ca_topic_score_gemma":0.00003925548,"domain_scores_codex":[0.9977756,0.0002173644,0.0007128237,0.0002586318,0.000695397,0.0003402276],"domain_scores_gemma":[0.9985292,0.0001135508,0.0002736819,0.000302019,0.0003689505,0.0004126066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01017739,0.0005034236,0.01934241,0.0001313889,0.00005691186,0.002975999,0.0002171601,0.000002960678,0.959981,0.000004090125,0.002160338,0.004446909],"study_design_scores_gemma":[0.002003799,0.0003696117,0.1081056,0.0002999481,0.00007301814,0.000172426,0.0004536361,0.00001250742,0.8853049,0.00002409655,0.003028793,0.0001517346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961133,0.001506894,0.0002598061,0.001096371,0.0003942114,0.0003743095,0.00008344821,0.00001087123,0.0001608031],"genre_scores_gemma":[0.9949296,0.0001591062,0.0005496845,0.0002914604,0.0003794296,0.000007574748,0.000004673332,0.00002283987,0.003655707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08876318,"threshold_uncertainty_score":0.6089736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105600951884783,"score_gpt":0.2570387160612821,"score_spread":0.2459827065424343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}