{"id":"W3169197984","doi":"10.1093/rheumatology/keab474","title":"Effect of the phosphodiesterase 4 inhibitor apremilast on cardiometabolic outcomes in psoriatic disease—results of the Immune Metabolic Associations in Psoriatic Arthritis study","year":2021,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"British Heart Foundation; Amgen","keywords":"Apremilast; Medicine; Psoriatic arthritis; Psoriasis; Disease; Immunology; Immune system; Dermatology; Arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000586108,0.0001974821,0.0005174705,0.00007382426,0.00007391616,0.00001814548,0.0002106846,0.00009693368,0.000003912965],"category_scores_gemma":[0.001367819,0.000127139,0.000293549,0.0005639246,0.00005973542,0.000009416749,0.0001793166,0.0001521031,0.000001619979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003578234,"about_ca_system_score_gemma":0.0001163419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001535416,"about_ca_topic_score_gemma":0.0007067107,"domain_scores_codex":[0.9977206,0.0008289176,0.0006055761,0.0003087691,0.0003372565,0.0001988649],"domain_scores_gemma":[0.9986404,0.0001409155,0.0003550035,0.0007358696,0.00008623186,0.0000416084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007948696,0.00138731,0.9390159,0.00007760467,0.0004349279,0.000008160651,0.001065689,0.002560895,0.04614927,0.00009088043,0.0001152289,0.008299301],"study_design_scores_gemma":[0.004272393,0.0001475883,0.850588,0.00008422957,0.00009894992,7.781237e-7,0.0001027246,0.00003762307,0.144086,0.00001874704,0.0004495812,0.0001134539],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947686,0.003016356,0.000003147039,0.0002335539,0.0009747387,0.000724643,0.000180671,0.000005531206,0.00009277124],"genre_scores_gemma":[0.9992162,0.0001975125,0.000006737769,0.00007006266,0.00008282997,0.00008583324,0.00006288137,0.00001710452,0.0002608477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09793671,"threshold_uncertainty_score":0.5184579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005691937332563112,"score_gpt":0.2429630667145804,"score_spread":0.2372711293820173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}