{"id":"W3169197984","doi":"10.1093/rheumatology/keab474","title":"Effect of the phosphodiesterase 4 inhibitor apremilast on cardiometabolic outcomes in psoriatic disease—results of the Immune Metabolic Associations in Psoriatic Arthritis study","year":2021,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"British Heart Foundation; Amgen","keywords":"Apremilast; Medicine; Psoriatic arthritis; Psoriasis; Disease; Immunology; Immune system; Dermatology; Arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002302069,0.0006237208,0.001532897,0.0002057153,0.0002750847,0.0006015302,0.0002623546,0.0006962237,0.001147497],"category_scores_gemma":[0.001625317,0.0002695814,0.001236612,0.0002428871,0.0002489048,0.0003085651,0.0003562261,0.001063698,0.0001986507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717429,"about_ca_system_score_gemma":0.0003029855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005347179,"about_ca_topic_score_gemma":0.0009830934,"domain_scores_codex":[0.9990237,0.0006063486,0.00007765029,0.0001192152,0.0001118134,0.00006131739],"domain_scores_gemma":[0.9986527,0.0003500742,0.0003567068,0.0001278012,0.0000803086,0.0004323935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6624026,0.01164087,0.2148414,0.0008303093,0.01134587,0.0002872403,0.0001467545,0.0008217738,0.01008234,0.00007550228,0.001252595,0.08627281],"study_design_scores_gemma":[0.06324799,0.135853,0.7904912,0.00008776614,0.00572409,0.0004588922,0.00007406667,0.0009892174,0.00156213,0.000117036,0.001354731,0.00003992337],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941539,0.004385199,0.0001219904,0.0001561886,0.00004928707,0.0001089626,0.0003757313,0.00001335128,0.0006353337],"genre_scores_gemma":[0.9973208,0.001229866,0.0002484741,0.0001759611,0.0001314938,0.00006360915,0.0004440437,0.000003603422,0.0003820646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002302069,"threshold_uncertainty_score":0.01217461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005691937332563112,"score_gpt":0.2429630667145804,"score_spread":0.2372711293820173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}