{"id":"W3169209842","doi":"10.1007/s40272-021-00459-x","title":"Laboratory Safety of Dupilumab in Patients Aged 6–11 Years with Severe Atopic Dermatitis: Results from a Phase III Clinical Trial","year":2021,"lang":"en","type":"article","venue":"Pediatric Drugs","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; Queen's University","funders":"Sanofi Genzyme; Regeneron Pharmaceuticals; Sanofi","keywords":"Medicine; Atopic dermatitis; Dupilumab; Placebo; Adverse effect; Internal medicine; Eczema Area and Severity Index; Concomitant; Randomized controlled trial; Gastroenterology; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002084701,0.0006797091,0.001422292,0.0001403609,0.0003280297,0.0007534372,0.0004838092,0.001054497,0.002262653],"category_scores_gemma":[0.001407977,0.000239878,0.001432304,0.0002355215,0.0004993065,0.0003763816,0.0001819949,0.001868917,0.0003511158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005529309,"about_ca_system_score_gemma":0.0009048308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003580876,"about_ca_topic_score_gemma":0.001186694,"domain_scores_codex":[0.9993615,0.0003568837,0.00004665002,0.00008039979,0.00007565938,0.00007896593],"domain_scores_gemma":[0.9983803,0.000448983,0.0005458107,0.00008658588,0.0001508014,0.0003874937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8549471,0.01421008,0.02125106,0.002585535,0.00311583,0.0004015717,0.000199894,0.000863025,0.01780459,0.0001462792,0.003397583,0.0810774],"study_design_scores_gemma":[0.6804687,0.2717512,0.03863047,0.0001830483,0.002001427,0.0006729866,0.000067118,0.0006938195,0.002736906,0.0001158669,0.002650318,0.00002807945],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854016,0.01031659,0.0003315583,0.0005402048,0.0001281391,0.001137329,0.0007936365,0.00004218521,0.001308617],"genre_scores_gemma":[0.9920269,0.00353073,0.0008062455,0.0007802009,0.0002346577,0.001133253,0.0009342556,0.000008526003,0.0005453273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262653,"threshold_uncertainty_score":0.01102507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311782862438619,"score_gpt":0.2921856871315576,"score_spread":0.2790678585071714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}