{"id":"W3169246075","doi":"10.1093/neuonc/noab090.008","title":"ATRT-09. IDENTIFICATION OF POTENTIAL GENETIC DRIVERS OF METHOTREXATE (MTX) RESISTANCE IN ATYPICAL TERATOID RHABDOID TUMOURS (ATRT) THROUGH A GENOME-WIDE RNAI SCREEN","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Biology; Transfection; RNA interference; Cancer research; Small hairpin RNA; Gene; Blot; Cell culture; Molecular biology; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003175772,0.0003891803,0.0004993344,0.0004453935,0.0002279861,0.000353568,0.0004139541,0.0003960123,0.002576528],"category_scores_gemma":[0.0001822495,0.0002142378,0.0004307453,0.0003423326,0.000200767,0.0001120875,0.0001828257,0.0006809667,0.001160565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003438545,"about_ca_system_score_gemma":0.0002750889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000949152,"about_ca_topic_score_gemma":0.003315552,"domain_scores_codex":[0.9997328,0.00002661413,0.00002751581,0.00005470627,0.000125933,0.00003242121],"domain_scores_gemma":[0.9998251,0.00004103602,0.00005550129,0.00001885276,0.00001969345,0.00003989131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008451357,0.00005471562,0.0004376959,0.00006036239,0.00001790848,0.0001593351,0.00001319937,0.0002000916,0.9961934,0.00009506858,0.0002963271,0.00238736],"study_design_scores_gemma":[0.00009179417,0.0009315853,0.01392252,0.00002217721,0.0001649845,0.001918258,0.00005421954,0.006515501,0.9629605,0.00006604917,0.01333434,0.00001812535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625115,0.001949692,0.01388744,0.0002484299,0.00006833459,0.0006107318,0.01367624,0.001053308,0.005994266],"genre_scores_gemma":[0.9363118,0.002297669,0.02206373,0.000254338,0.00001744869,0.0004902531,0.02541695,0.0003247605,0.01282315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576528,"threshold_uncertainty_score":0.008619368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721175098722627,"score_gpt":0.2911656772268459,"score_spread":0.2739539262396196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}