{"id":"W3169256362","doi":"10.1101/2021.06.07.447350","title":"Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition <i>in cell</i> and is negatively affected in the UBTF-E210K neuroregression syndrome","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Université Laval; Génome Québec; Institute of Museum and Library Services","keywords":"Promoter; Biology; RNA polymerase II; RNA polymerase I; Genetics; Gene; RNA polymerase III; Enhancer; RNA polymerase; RNA; Molecular biology; Cell biology; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257072,0.001014242,0.0003224559,0.0006930035,0.0003855524,0.0002994644,0.0004072331,0.0005958882,0.004341574],"category_scores_gemma":[0.0001803187,0.0002910424,0.0003405941,0.0002059611,0.0007076143,0.0001220847,0.0004016989,0.0005202318,0.001117504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996452,"about_ca_system_score_gemma":0.0001842021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044547,"about_ca_topic_score_gemma":0.00124386,"domain_scores_codex":[0.9997965,0.00002136124,0.0000276236,0.00006716618,0.00005262179,0.00003476274],"domain_scores_gemma":[0.9996785,0.00004341641,0.0001191137,0.00001913072,0.00001369048,0.0001261191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002155062,0.00002592226,0.001701218,0.00002610196,0.00001880308,0.00181795,0.00003389607,0.0001145074,0.9946417,0.0001561258,0.00008764438,0.001160487],"study_design_scores_gemma":[0.0001482315,0.0006073035,0.1137591,0.00004544238,0.0001865208,0.03340026,0.0003320781,0.004022192,0.8394801,0.0005480777,0.007419535,0.0000511225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973531,0.0002820877,0.001049651,0.00006741531,0.00002129664,0.000007862816,0.0004633875,0.0001154222,0.0006398112],"genre_scores_gemma":[0.997462,0.000123151,0.000651929,0.00003918604,0.000009332486,0.00001148473,0.0003664949,0.00006186002,0.001274553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004341574,"threshold_uncertainty_score":0.01452398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01495798307720977,"score_gpt":0.2255491111060642,"score_spread":0.2105911280288545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}