{"id":"W3169342710","doi":"10.1126/scitranslmed.abf6348","title":"A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; Alzheimer Nadační Fond; Mount Allison University; Coalition for Epidemic Preparedness Innovations; Brotherhood of St Laurence; Society of Abdominal Radiology","keywords":"Lassa virus; Virology; Heterologous; Lassa fever; Immunity; Biology; Immunology; Vaccine efficacy; Medicine; Virus; Immune system; Vaccination; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006917535,0.0001893071,0.0003340615,0.0003798755,0.0004626053,0.00005039436,0.0001376818,0.00008017669,0.0003177211],"category_scores_gemma":[0.0003388493,0.0001432159,0.0000525851,0.001270552,0.0009495352,0.0003167707,0.00005107466,0.0004732511,0.00000865831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007204349,"about_ca_system_score_gemma":0.0005012245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008478296,"about_ca_topic_score_gemma":0.0001992644,"domain_scores_codex":[0.9977493,0.00008091928,0.0003434509,0.0004793672,0.0009024616,0.0004444938],"domain_scores_gemma":[0.9987064,0.00009300154,0.00006194258,0.0002762628,0.000499517,0.0003628923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000091668,0.0002910978,0.02944876,0.0001047082,0.00003821124,0.0002389539,0.0007063972,0.00001848485,0.9077988,0.0001608975,0.00001855713,0.0610835],"study_design_scores_gemma":[0.003177076,0.001136702,0.9243155,0.0003553558,0.00005257591,0.0007481026,0.0001651191,0.0008100282,0.06865258,0.0002760556,0.0001190133,0.0001919109],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829766,0.0007678037,0.0006879005,0.01042742,0.0001573365,0.0004803062,0.00001149961,0.00005744792,0.004433736],"genre_scores_gemma":[0.998323,0.0001239028,0.0003485373,0.0006392967,0.0002413101,0.00002576569,0.00007294794,0.00001349707,0.0002116973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8948667,"threshold_uncertainty_score":0.5840173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08374845003695965,"score_gpt":0.3610445863274067,"score_spread":0.2772961362904471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}