{"id":"W3169399702","doi":"10.1200/jco.2021.39.15_suppl.6036","title":"Final analysis of a phase 1b, randomized, multicenter study of talimogene laherparepvec (T-VEC) plus pembrolizumab (pembro) combination for the treatment (Tx) of recurrent/metastatic squamous cell carcinoma of the head and neck (R/M HNSCC): MASTERKEY-232.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Amgen","keywords":"Medicine; Pembrolizumab; Internal medicine; Oncolytic virus; Oncology; Refractory (planetary science); Cancer; Surgery; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004816417,0.001974109,0.002006882,0.0004241968,0.0006422694,0.001490027,0.001132317,0.001833666,0.008436854],"category_scores_gemma":[0.002618483,0.000870759,0.002080171,0.0005184287,0.0008934273,0.001046578,0.0005911055,0.002922164,0.002012722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00133937,"about_ca_system_score_gemma":0.003010802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011185,"about_ca_topic_score_gemma":0.003245885,"domain_scores_codex":[0.9986608,0.0007672585,0.00006003131,0.0001951397,0.000108792,0.0002079229],"domain_scores_gemma":[0.998521,0.0002573298,0.0003008811,0.0001565886,0.0001828755,0.0005812843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9352626,0.01434787,0.0039397,0.0006935902,0.002544644,0.000120528,0.0001722419,0.0009067209,0.01157294,0.0003162637,0.007908783,0.02221405],"study_design_scores_gemma":[0.8798115,0.1037051,0.008295497,0.00004213944,0.001384474,0.0001188404,0.00005251339,0.000559863,0.001110901,0.0002858287,0.004605349,0.00002800962],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335113,0.003697825,0.002372202,0.002354692,0.000585276,0.03044409,0.01995144,0.0003595892,0.006723581],"genre_scores_gemma":[0.9314839,0.001933586,0.006903424,0.003487955,0.0004529822,0.02342204,0.02282916,0.0001630128,0.009323921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008436854,"threshold_uncertainty_score":0.02822411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110837465633524,"score_gpt":0.4540985133859306,"score_spread":0.3430147668225783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}