{"id":"W3169457819","doi":"10.1101/2021.06.07.447369","title":"Effects of early life adversity on immediate early gene expression: systematic review and 3-level meta-analysis of rodent studies","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Stressor; Meta-analysis; Expression (computer science); Psychology; Immediate early gene; Biology; Neuroscience; Gene expression; Developmental psychology; Gene; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01119304,0.001797209,0.009552535,0.005796676,0.0005168491,0.002760324,0.001580314,0.001237024,0.00486437],"category_scores_gemma":[0.03285554,0.0008360214,0.01811605,0.007635905,0.0007171599,0.00130034,0.001702896,0.001206756,0.0005428456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001471441,"about_ca_system_score_gemma":0.003955605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004985381,"about_ca_topic_score_gemma":0.0113911,"domain_scores_codex":[0.9922821,0.003074977,0.002357343,0.001165332,0.0008567186,0.0002633852],"domain_scores_gemma":[0.9719852,0.02193022,0.003219558,0.0009526475,0.001661081,0.0002513805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0009488335,0.00002276844,0.008116096,0.6794531,0.2821538,0.0001762031,0.0001626055,0.0003895474,0.000555747,0.0003168978,0.001796745,0.02590765],"study_design_scores_gemma":[0.0003025815,0.0001981611,0.0142477,0.1169717,0.8568459,0.0002292269,0.0001325724,0.0001390209,0.0003346443,0.0006834748,0.009869277,0.00004580525],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.003177304,0.9933594,0.0008402554,0.0002694622,0.0001239745,0.0001415176,0.00180563,0.00002605062,0.0002564177],"genre_scores_gemma":[0.1188663,0.8732994,0.002760166,0.001089216,0.0002306663,0.0008895427,0.002463607,0.00006618509,0.0003349097],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01119304,"threshold_uncertainty_score":0.05919516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06915280131166729,"score_gpt":0.2777991235237,"score_spread":0.2086463222120327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}