{"id":"W3169473968","doi":"10.1101/2021.03.31.437507","title":"Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mitochondrion; Mitochondrial DNA; Biology; Cell biology; Lysosome; Mitochondrial disease; Mitophagy; Autophagy; Internal medicine; Biochemistry; Medicine; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820966,0.0003260834,0.0003071349,0.0003536798,0.0002933943,0.0002470177,0.0001012616,0.0003850438,0.001041682],"category_scores_gemma":[0.000243545,0.0001116893,0.0003480007,0.0001448073,0.0001690862,0.0001509288,0.0001660739,0.0002900098,0.000269907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001638212,"about_ca_system_score_gemma":0.0001052157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009018515,"about_ca_topic_score_gemma":0.0008525967,"domain_scores_codex":[0.9998333,0.000037158,0.00002825915,0.00004163269,0.00003504299,0.00002450227],"domain_scores_gemma":[0.9998612,0.00003729216,0.00002706408,0.00001322561,0.00002145135,0.00003975526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002146286,0.0001420196,0.01162757,0.0001088664,0.00005819714,0.00375505,0.0001457586,0.0001307342,0.9766974,0.00004353396,0.0001689314,0.004975639],"study_design_scores_gemma":[0.0001506441,0.004835333,0.1578791,0.00003026148,0.0001702605,0.02576772,0.0006348741,0.002246801,0.8043768,0.00009146285,0.003787572,0.00002918676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971199,0.001715305,0.0003162331,0.00006409817,0.00003655128,0.00001706372,0.0002457055,0.00002450141,0.0004605526],"genre_scores_gemma":[0.9987117,0.0003624457,0.0003980716,0.00002612002,0.000006826275,0.00001057619,0.0002209636,0.000003136739,0.0002601239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041682,"threshold_uncertainty_score":0.003484786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004308314545818096,"score_gpt":0.2011301960836054,"score_spread":0.1968218815377873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}