{"id":"W3169516549","doi":"10.18433/jpps32011","title":"Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacokinetics; Drug; Pharmacology; Prodrug; Physiologically based pharmacokinetic modelling; Medicine; Antiviral drug; Biopharmaceutical; Drug interaction; Biology; Biotechnology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004024555,0.0006907024,0.0008041001,0.000462998,0.000473203,0.0006953295,0.0007955912,0.001157125,0.004136169],"category_scores_gemma":[0.001457015,0.0004482622,0.001259284,0.0004776829,0.0003259143,0.000383322,0.0006216114,0.0007591416,0.0003619755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009779135,"about_ca_system_score_gemma":0.001795984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0210029,"about_ca_topic_score_gemma":0.008795227,"domain_scores_codex":[0.9998067,0.00006149786,0.0000111549,0.00002902976,0.00004948466,0.00004208931],"domain_scores_gemma":[0.9993396,0.0004215326,0.00006806543,0.00002329854,0.00009912487,0.00004839047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001704174,0.00007474497,0.003482547,0.00007402832,0.00005212633,0.000169274,0.00004131759,0.9907003,0.001391295,0.0009163474,0.0008004218,0.002127275],"study_design_scores_gemma":[0.00004878294,0.00006446359,0.0006020909,0.000008077465,0.00002564398,0.00004255354,0.00001989406,0.9968573,0.0008316174,0.00039775,0.001094299,0.000007449369],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8892967,0.00122518,0.06689816,0.001037349,0.0001738944,0.0003350732,0.005990542,0.001013585,0.03402943],"genre_scores_gemma":[0.974655,0.0005878672,0.01603995,0.000238146,0.00002439473,0.0003512224,0.002644042,0.0001310191,0.005328417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0210029,"threshold_uncertainty_score":0.04176128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2164999905811522,"score_gpt":0.5792282370005402,"score_spread":0.362728246419388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}