{"id":"W3169521721","doi":"10.1021/acs.langmuir.1c00530","title":"Scalable Production of Lipid Nanoparticles Containing Amphotericin B","year":2021,"lang":"en","type":"article","venue":"Langmuir","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Networks of Centres of Excellence of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Solubility; Nanoparticle; Combinatorial chemistry; Drug delivery; Drug; Solvent; Nanotechnology; Organic chemistry; Materials science; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005287968,0.00004978597,0.00007526016,0.0000112685,0.00002564026,0.00000710244,0.00004889064,0.00004004841,0.0000365884],"category_scores_gemma":[0.00004004544,0.00004682316,0.00003445642,0.00005898819,0.00002491434,0.000002536493,0.00004056012,0.00002284878,0.00001222799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003220457,"about_ca_system_score_gemma":0.00002634256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000135295,"about_ca_topic_score_gemma":0.00002240291,"domain_scores_codex":[0.9995844,0.00002330996,0.0000983746,0.0001496196,0.00004841009,0.00009585974],"domain_scores_gemma":[0.9997187,0.000002231309,0.00003421108,0.0001408062,0.00008665767,0.00001736594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003663834,0.00002822294,0.004350798,0.00001226112,0.00001698544,0.000002594992,0.00006876527,0.00001424686,0.9913735,0.00002644803,0.002579879,0.001489628],"study_design_scores_gemma":[0.0001123898,0.000106798,0.005027056,0.00001282001,0.000005705514,0.00001436557,0.0002159728,0.000008991547,0.9811173,0.00001500752,0.01330705,0.0000565159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980313,0.0004393787,0.00005650743,0.0001692978,0.0001678592,0.0000282604,0.000003025815,0.000006226284,0.00109821],"genre_scores_gemma":[0.9974625,0.00005598712,0.0002323902,0.0001343798,0.000183345,0.000004258053,0.00003868521,0.000006088224,0.001882409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01072717,"threshold_uncertainty_score":0.1909393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132445298828469,"score_gpt":0.241121224362307,"score_spread":0.2278766944794601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}