{"id":"W3169521721","doi":"10.1021/acs.langmuir.1c00530","title":"Scalable Production of Lipid Nanoparticles Containing Amphotericin B","year":2021,"lang":"en","type":"article","venue":"Langmuir","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Networks of Centres of Excellence of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Solubility; Nanoparticle; Combinatorial chemistry; Drug delivery; Drug; Solvent; Nanotechnology; Organic chemistry; Materials science; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002729178,0.000380218,0.0002574972,0.0002108804,0.0001876338,0.0003199815,0.0002669155,0.0004062957,0.0007540258],"category_scores_gemma":[0.0002250852,0.0002354876,0.0002369669,0.0001221813,0.0002181713,0.0003990333,0.0004822651,0.0006575198,0.0004558349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630787,"about_ca_system_score_gemma":0.0002593931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003038041,"about_ca_topic_score_gemma":0.0004789606,"domain_scores_codex":[0.9998652,0.00001687504,0.00001711112,0.00003958563,0.00004748464,0.00001378915],"domain_scores_gemma":[0.999902,0.00002462946,0.00002880566,0.00001364385,0.00001749317,0.00001334127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007167903,0.000006049355,0.000015449,0.00001909353,0.000001430721,0.00001804127,0.000006797478,0.00007360106,0.998868,0.00007758771,0.0000173896,0.0008893944],"study_design_scores_gemma":[0.0000122353,0.0000816755,0.0001520259,0.000003870096,0.0000052068,0.00005593873,0.000006388369,0.001099027,0.9971027,0.000048799,0.001428693,0.000003424189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8327088,0.002647887,0.1579104,0.000293557,0.00009335076,0.0005215209,0.0007413341,0.0008483492,0.004234849],"genre_scores_gemma":[0.8640187,0.002129198,0.1291247,0.00009605741,0.00001870425,0.0003996452,0.0008992729,0.0001330831,0.003180489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007540258,"threshold_uncertainty_score":0.002522469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132445298828469,"score_gpt":0.241121224362307,"score_spread":0.2278766944794601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}