{"id":"W3169554845","doi":"10.3389/fonc.2021.665273","title":"RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ryobi Teien Memory Foundation; Japan Society for the Promotion of Science; Princess Takamatsu Cancer Research Fund; Okinaka Memorial Institute for Medical Research; Uehara Memorial Foundation","keywords":"RUNX2; Cancer research; Transcription factor; Tyrosine kinase; Tyrosine phosphorylation; Phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Biology; ABL; Promoter; Cell biology; Signal transduction; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000948002,0.0002082211,0.0001483021,0.0001416412,0.00012031,0.0002223714,0.00006670578,0.0001199084,0.002324948],"category_scores_gemma":[0.00006399889,0.0000977662,0.0001703748,0.0001110807,0.0001098787,0.0001091323,0.000192882,0.0004322435,0.0004524679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935783,"about_ca_system_score_gemma":0.0001832722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004632878,"about_ca_topic_score_gemma":0.001253814,"domain_scores_codex":[0.9999299,0.000008688794,0.000003620392,0.000007967129,0.00002415424,0.00002565515],"domain_scores_gemma":[0.9999682,0.000005815169,0.000008138257,0.000002955526,0.00000350164,0.00001153627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001393989,0.00004274742,0.0002939401,0.00003051724,0.00000402153,0.00006347032,0.00001481383,0.00007571313,0.9976282,0.0001350331,0.000138137,0.001433996],"study_design_scores_gemma":[0.00005382967,0.0004007829,0.01513992,0.000007221291,0.00001822058,0.0004237903,0.00006037906,0.001805255,0.9747416,0.0001627127,0.007181106,0.000005153132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928173,0.001811855,0.0008554229,0.0002015383,0.00002317199,0.00001568933,0.0001935346,0.00007070716,0.004010736],"genre_scores_gemma":[0.9956214,0.0008301509,0.000436041,0.00003479448,0.00001029168,0.0000134604,0.0002072768,0.00001015608,0.002836393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324948,"threshold_uncertainty_score":0.007777691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209843121621047,"score_gpt":0.2841114313522879,"score_spread":0.2720130001360774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}