{"id":"W3169559325","doi":"10.1530/erc-21-0116","title":"Targeting androgen receptor signaling: a historical perspective","year":2021,"lang":"en","type":"review","venue":"Endocrine Related Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Prostate Cancer Canada; Prostate Cancer Foundation","keywords":"Prostate cancer; Medicine; Androgen deprivation therapy; Cancer; Disease; Hormonal therapy; Oncology; Prostate; Internal medicine; Androgen; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001562977,0.0005913049,0.002466348,0.0003113961,0.0001448235,0.00003414701,0.0001704798,0.0003325464,0.004665737],"category_scores_gemma":[0.0002187346,0.0004326947,0.0009408819,0.001040651,0.00006962101,0.00006087541,0.0001326976,0.001566533,0.0001986944],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01011339,"about_ca_system_score_gemma":0.002573072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004450425,"about_ca_topic_score_gemma":0.000002474862,"domain_scores_codex":[0.9968196,0.0002261794,0.0007344118,0.0009240557,0.0005586114,0.0007371432],"domain_scores_gemma":[0.9983444,0.0001531353,0.0002872832,0.0004086626,0.0004382615,0.0003682818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001364769,0.0004593995,0.00006451425,0.01258654,0.006868933,0.004634303,0.0004637318,0.000005556406,0.00006660987,0.0003485071,0.1112584,0.8631071],"study_design_scores_gemma":[0.001239049,0.0001589594,1.513449e-7,0.01373256,0.002362382,0.0003354719,0.00009622217,0.000003782094,0.00007683339,0.0000138941,0.9815805,0.0004002071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008318857,0.9936734,0.000002965764,0.0009481904,0.0009173811,0.001243225,0.00007543784,0.0001561327,0.002974927],"genre_scores_gemma":[0.000004786787,0.9450457,0.0001760472,0.00003081382,0.0008873211,0.0006464846,0.0005854274,0.0001560701,0.05246738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8703221,"threshold_uncertainty_score":0.9998125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05901755478858615,"score_gpt":0.3948831400957289,"score_spread":0.3358655853071427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}