{"id":"W3169590529","doi":"10.1096/fasebj.2021.35.s1.02762","title":"Kynurenine Metabolism in the D2 <i>mdx</i> Mouse: A Muscle‐to‐Brain Connection","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Kynurenine; Kynurenine pathway; Kynurenic acid; Quinolinic acid; Neuroprotection; Dystrophin; mdx mouse; Metabolite; Duchenne muscular dystrophy; Chemistry; Biology; Internal medicine; Endocrinology; Neuroscience; Pharmacology; Biochemistry; Medicine; Glutamate receptor; Tryptophan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004379412,0.001188318,0.0008213799,0.002179021,0.0007571472,0.0009932886,0.0007762482,0.002252676,0.007584674],"category_scores_gemma":[0.0001756461,0.0006627596,0.0009532761,0.0006249639,0.001642733,0.0009364506,0.0007570349,0.003441522,0.001807186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001068508,"about_ca_system_score_gemma":0.0005035527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002692818,"about_ca_topic_score_gemma":0.004704673,"domain_scores_codex":[0.9993315,0.00004239158,0.00008214052,0.0002843156,0.0001517423,0.000107828],"domain_scores_gemma":[0.9992602,0.00005220688,0.0002843984,0.00004111799,0.00005539223,0.0003066935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008709635,0.0002194215,0.000831771,0.0001843257,0.00002409852,0.0004038698,0.00008737947,0.0001111243,0.9947391,0.000549485,0.0003835574,0.001594926],"study_design_scores_gemma":[0.0003322671,0.002187001,0.03944919,0.000265801,0.0002079197,0.002691545,0.0007378247,0.001762821,0.9339985,0.001013896,0.01725435,0.00009912708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554954,0.005024692,0.01131812,0.001960467,0.0003662885,0.0002752572,0.01901176,0.0008696191,0.005678435],"genre_scores_gemma":[0.919714,0.005164725,0.01698165,0.00143471,0.0001029817,0.001051473,0.00878952,0.0006780675,0.04608279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007584674,"threshold_uncertainty_score":0.02537322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02477100935422872,"score_gpt":0.2597151919287301,"score_spread":0.2349441825745014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}