{"id":"W3169648361","doi":"10.1101/2021.06.04.447122","title":"A Novel Organoid Model of In Vitro Spermatogenesis Using Human Induced Pluripotent Stem Cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Ottawa Hospital; University of British Columbia","funders":"","keywords":"Organoid; Spermatogenesis; Induced pluripotent stem cell; Biology; Somatic cell; Cell biology; Spermatid; Stem cell; In vitro; Male infertility; Infertility; Genetics; Embryonic stem cell; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002648386,0.0003851334,0.0003144386,0.000395943,0.000269844,0.0005833527,0.0005309362,0.0005222617,0.001463667],"category_scores_gemma":[0.0001038706,0.0002323669,0.0004618039,0.0003157402,0.0004480597,0.0002840978,0.0004975548,0.0005765427,0.000506527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003854311,"about_ca_system_score_gemma":0.0005820616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001690309,"about_ca_topic_score_gemma":0.001793914,"domain_scores_codex":[0.9998111,0.00002876886,0.00001577995,0.00005826998,0.00007230222,0.00001380379],"domain_scores_gemma":[0.9998499,0.00002478065,0.00003019626,0.00003690078,0.00001840299,0.00003984568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005205788,0.0000262236,0.0002463034,0.000125414,0.00001380315,0.0003499659,0.0000778385,0.003189816,0.9905551,0.002370075,0.0002909299,0.002702425],"study_design_scores_gemma":[0.0000389726,0.000370015,0.001514527,0.00004075908,0.0000450373,0.0008795246,0.00005927991,0.01482358,0.9509491,0.0008377018,0.03041268,0.00002895515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5270544,0.005341675,0.4410876,0.000525717,0.0008069681,0.0004943833,0.005474039,0.002013932,0.01720131],"genre_scores_gemma":[0.8683307,0.001782724,0.1144093,0.0001158841,0.00003116521,0.000244447,0.002524278,0.0001535879,0.01240792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001690309,"threshold_uncertainty_score":0.004896522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03613258460293729,"score_gpt":0.2522544641867922,"score_spread":0.2161218795838549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}