{"id":"W3169696692","doi":"10.3390/v13061055","title":"A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In Vitro","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Queen's University","funders":"","keywords":"Biosensor; Mutant; In vitro; Virus; Coronavirus; Virology; Receptor; Biology; High-throughput screening; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Chemistry; Angiotensin-converting enzyme 2; Drug discovery; Coronavirus disease 2019 (COVID-19); Computational biology; Biochemistry; Gene; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237521,0.00008993037,0.0002165005,0.0001639019,0.00002750752,0.00002214315,0.00004214548,0.00006035987,0.000001737784],"category_scores_gemma":[0.0003628086,0.00006585316,0.00003293898,0.0002742394,0.0000526768,0.00007916897,0.00005716703,0.0001296824,0.000004783409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003864337,"about_ca_system_score_gemma":0.00007357888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002208659,"about_ca_topic_score_gemma":0.0003290441,"domain_scores_codex":[0.9992194,0.00006291702,0.0002186031,0.0002138595,0.0001138452,0.0001713479],"domain_scores_gemma":[0.9994117,0.0003243336,0.00004792953,0.000126685,0.00007802501,0.00001133897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000954213,0.0001181425,0.01208539,0.0002550229,0.00001550991,0.00001169074,0.0003873693,5.075712e-8,0.9838407,0.00001371707,0.000103074,0.00221512],"study_design_scores_gemma":[0.001181225,0.00007580821,0.001220396,0.0001989359,0.00001142429,0.000009726604,0.0006779943,0.0004347302,0.962288,0.000006550024,0.03383277,0.00006250497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974248,0.0015915,0.000005582525,0.0004113581,0.0001089331,0.0003933775,0.00002216652,0.000008694578,0.00003359569],"genre_scores_gemma":[0.9930136,0.0001143102,0.000126717,0.006646576,0.00004759792,0.00003122268,0.000001647137,0.00001300711,0.00000538614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03372969,"threshold_uncertainty_score":0.2685414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648730206378423,"score_gpt":0.4112879917215645,"score_spread":0.2464149710837222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}