{"id":"W3169696692","doi":"10.3390/v13061055","title":"A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In Vitro","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Queen's University","funders":"","keywords":"Biosensor; Mutant; In vitro; Virus; Coronavirus; Virology; Receptor; Biology; High-throughput screening; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Chemistry; Angiotensin-converting enzyme 2; Drug discovery; Coronavirus disease 2019 (COVID-19); Computational biology; Biochemistry; Gene; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001068416,0.0009574422,0.0005901491,0.0003702016,0.0003167076,0.0004831338,0.0008031566,0.001140629,0.0008571232],"category_scores_gemma":[0.0005776051,0.0003445397,0.0004089945,0.0003210102,0.0003899135,0.0005354161,0.0004602223,0.001414344,0.0004788695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006180989,"about_ca_system_score_gemma":0.0004459885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008128842,"about_ca_topic_score_gemma":0.001171647,"domain_scores_codex":[0.9990739,0.0003087714,0.00004816658,0.0001835544,0.0003142677,0.00007134401],"domain_scores_gemma":[0.9997769,0.00008763275,0.00003540133,0.00002440809,0.00004244988,0.00003327738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002125606,0.00002837918,0.00005798259,0.00003175932,0.000003859562,0.00001472296,0.00001234614,0.00007552093,0.9986224,0.0001084162,0.00006316204,0.0009602425],"study_design_scores_gemma":[0.00001416804,0.0001852926,0.0004017196,0.00000585385,0.000009004835,0.0001160582,0.00002358103,0.004351933,0.9932665,0.00005334698,0.001560778,0.00001180648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5649998,0.006145907,0.4181588,0.001421113,0.0005235189,0.0003826328,0.0009066017,0.001220508,0.006241027],"genre_scores_gemma":[0.6647744,0.003694212,0.3227823,0.000739364,0.0000782046,0.00068638,0.0008374904,0.00006403169,0.006343656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140629,"threshold_uncertainty_score":0.005650401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648730206378423,"score_gpt":0.4112879917215645,"score_spread":0.2464149710837222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}