{"id":"W3169755981","doi":"10.1093/ecco-jcc/jjab157","title":"The Effect of Phenotype and Genotype on the Plasma Proteome in Patients with Inflammatory Bowel Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Takeda Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Rijksuniversiteit Groningen","keywords":"Genotype; Phenotype; Inflammatory bowel disease; Biology; Proteome; Immunology; Ulcerative colitis; Disease; Crohn's disease; Expression quantitative trait loci; Gene; Chemokine; CCL17; Inflammation; Genetics; CXCL10; Single-nucleotide polymorphism; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002318253,0.00008890183,0.00009834014,0.00001582562,0.00007870586,0.00003102408,0.00007657884,0.00003581304,0.000005238482],"category_scores_gemma":[0.0001124061,0.00004622492,0.00003871757,0.00003189376,0.0001172795,0.000005890714,0.00004490258,0.00009254136,3.752657e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008264909,"about_ca_system_score_gemma":0.0001233006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.674956e-7,"about_ca_topic_score_gemma":0.00001444938,"domain_scores_codex":[0.9993082,0.0001371312,0.0001891026,0.00009107137,0.0001597048,0.0001148504],"domain_scores_gemma":[0.9994231,0.00004454641,0.0001523609,0.0001486535,0.0001396671,0.00009167282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05317058,0.0001140518,0.9383913,0.0003021112,0.0002426592,0.0007293274,0.0001199797,0.00007290964,0.0008078503,0.0007928284,0.0003074302,0.004948974],"study_design_scores_gemma":[0.001297625,0.0005128246,0.9949299,0.00009112593,0.00003054774,0.000005512597,0.00002366134,0.000007989928,0.002263401,0.00006254498,0.000714704,0.00006012778],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990075,0.0005293975,0.000001676897,0.0001270072,0.00004311334,0.0001988898,0.00001294583,6.76049e-7,0.0000787917],"genre_scores_gemma":[0.9996896,0.0001298474,0.00000904184,0.00005046096,0.00005274359,0.000008874739,0.000002487384,0.000008860357,0.00004804681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05653863,"threshold_uncertainty_score":0.1884998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002383621096927864,"score_gpt":0.1901516246437747,"score_spread":0.1877680035468469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}