{"id":"W3169755981","doi":"10.1093/ecco-jcc/jjab157","title":"The Effect of Phenotype and Genotype on the Plasma Proteome in Patients with Inflammatory Bowel Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Takeda Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Rijksuniversiteit Groningen","keywords":"Genotype; Phenotype; Inflammatory bowel disease; Biology; Proteome; Immunology; Ulcerative colitis; Disease; Crohn's disease; Expression quantitative trait loci; Gene; Chemokine; CCL17; Inflammation; Genetics; CXCL10; Single-nucleotide polymorphism; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005228195,0.0003912038,0.0003726768,0.0005479536,0.0002178153,0.0004892722,0.000156458,0.0005058339,0.001252158],"category_scores_gemma":[0.001602556,0.0001364843,0.0002915982,0.0006443436,0.0002619377,0.0002583776,0.000281016,0.0003572752,0.0001951401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066823,"about_ca_system_score_gemma":0.00007148334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003064995,"about_ca_topic_score_gemma":0.0003226025,"domain_scores_codex":[0.999513,0.0001902715,0.00005014424,0.0001388056,0.00006354666,0.00004424074],"domain_scores_gemma":[0.9989913,0.0003708742,0.0003934921,0.00006983639,0.00007013045,0.000104373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001109371,0.00002644443,0.9860989,0.00003376138,0.0001684369,0.0002978905,0.00007928113,0.0001053686,0.008354502,0.00002527049,0.00009855449,0.003602262],"study_design_scores_gemma":[0.000008156873,0.0001424257,0.9982852,0.000004671509,0.00004583953,0.0006869709,0.00005164672,0.0002016374,0.0003989739,0.00004059422,0.0001306149,0.000003224234],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988015,0.0005574302,0.0001885753,0.00004541432,0.000006251504,0.000001947137,0.0001990508,0.000004828863,0.0001948822],"genre_scores_gemma":[0.9995346,0.0000852598,0.0001376524,0.00002507965,0.000008362712,0.000002447457,0.0001519555,0.000002842809,0.0000518432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252158,"threshold_uncertainty_score":0.004188836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002383621096927864,"score_gpt":0.1901516246437747,"score_spread":0.1877680035468469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}