{"id":"W3169767899","doi":"10.1093/ndt/gfab104.0044","title":"MO286DESIGN OF A PH1, MULTICENTER TRIAL TO INVESTIGATE THE SAFETY, TOLERABILITY, PK/PD OF BION-1301 IN HEALTHY VOLUNTEERS AND ADULTS WITH IGAN AND A MULTICENTER, OPEN-LABEL EXTENSION STUDY FOR IGAN PATIENTS WHO PARTICIPATED IN A PRIOR TRIAL OF BION-1301","year":2021,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Chinook Regional Hospital","funders":"","keywords":"Medicine; Tolerability; Kidney disease; Immunology; Immunogenicity; Renal function; Nephropathy; Glomerulonephritis; Internal medicine; Gastroenterology; Dialysis; Proteinuria; Kidney; Antibody; Endocrinology; Adverse effect; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003365714,0.002179473,0.001781129,0.0004069385,0.0005811069,0.0009547394,0.0008401609,0.001854901,0.005636844],"category_scores_gemma":[0.001656359,0.0006410124,0.001746444,0.0002478373,0.001365082,0.001210616,0.0006140071,0.003419693,0.001113027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009786848,"about_ca_system_score_gemma":0.001431578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005076373,"about_ca_topic_score_gemma":0.0008749799,"domain_scores_codex":[0.9985365,0.00078678,0.00004675798,0.0003078109,0.00008724601,0.0002348733],"domain_scores_gemma":[0.9981383,0.0002941793,0.0002860822,0.0001468533,0.0001095102,0.001025166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9328488,0.03446094,0.003101659,0.0002637819,0.0005271585,0.0001430741,0.0001161426,0.0004787044,0.008176994,0.0001519179,0.000983602,0.01874734],"study_design_scores_gemma":[0.5369986,0.4531874,0.006733119,0.0000154486,0.0002223318,0.00008818275,0.0000236265,0.0004536284,0.0009969037,0.0001551288,0.001102244,0.00002346684],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9907675,0.001113258,0.0004828663,0.0004121942,0.000172374,0.004449531,0.0011072,0.00006665083,0.001428446],"genre_scores_gemma":[0.9876736,0.00052776,0.001424519,0.000773554,0.0003520159,0.005235753,0.001520856,0.00002232524,0.002469652],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005636844,"threshold_uncertainty_score":0.01885712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03196364679241989,"score_gpt":0.3204319175150949,"score_spread":0.288468270722675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}