{"id":"W3169823111","doi":"10.1016/j.tcb.2021.05.006","title":"Polycomb repressive complex 2 in the driver’s seat of childhood and young adult brain tumours","year":2021,"lang":"en","type":"review","venue":"Trends in Cell Biology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Génome Québec; National Cancer Institute; Genome Canada","keywords":"Biology; Carcinogenesis; Epigenetics; Chromatin; Epigenome; Epigenesis; Histone; Glioma; Cancer research; Genetics; Neuroscience; Cell biology; Cancer; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005039707,0.0005883474,0.001338557,0.001171071,0.0001609426,0.0007433298,0.0008200516,0.0008049065,0.003565315],"category_scores_gemma":[0.0005904101,0.0001982029,0.0004068421,0.001107172,0.0003462648,0.0007719907,0.0005446016,0.001612623,0.001845089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005729595,"about_ca_system_score_gemma":0.001046763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00155163,"about_ca_topic_score_gemma":0.003857333,"domain_scores_codex":[0.9998636,0.00002097887,0.00002015194,0.0000247792,0.00005341548,0.00001710853],"domain_scores_gemma":[0.9997706,0.0001027985,0.00003649154,0.000005187193,0.00005719268,0.00002773679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001242015,0.00003310018,0.0003175561,0.0108658,0.0001405153,0.0002334859,0.00003278163,0.000325193,0.001549977,0.002909189,0.03844835,0.9450198],"study_design_scores_gemma":[0.00004132499,0.00007935605,0.001590407,0.00271196,0.0002035923,0.00104244,0.00004116576,0.0001130407,0.000459104,0.001943652,0.9917532,0.00002086649],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001050503,0.9988554,0.00008025039,0.0003008235,0.0001673618,0.00000226564,0.00002604002,0.000006993494,0.0004558929],"genre_scores_gemma":[0.0007525345,0.9982174,0.00009399722,0.0002310507,0.0001683527,0.000002647461,0.00005279161,0.000001427949,0.0004797716],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003565315,"threshold_uncertainty_score":0.01192713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04650324022607463,"score_gpt":0.357096588730324,"score_spread":0.3105933485042494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}