{"id":"W3169877630","doi":"10.1101/2021.06.04.446995","title":"Prior induction of cellular antiviral pathways limits frog virus 3 replication in two permissive <i>Xenopus laevis</i> skin epithelial-like cell lines","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Biology; Xenopus; Permissiveness; Cell culture; Ranavirus; Proinflammatory cytokine; Cell biology; Cytopathic effect; Viral replication; Organ culture; Amphibian; In vitro; Virus; Virology; Immunology; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581341,0.0002562814,0.0001989867,0.0001626737,0.00016867,0.0003432041,0.0002311981,0.0002351721,0.001883173],"category_scores_gemma":[0.0001307752,0.0001156492,0.0002788071,0.0001176081,0.0001744497,0.0001824075,0.0002392152,0.0004550406,0.0006980677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474991,"about_ca_system_score_gemma":0.0001099879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008398104,"about_ca_topic_score_gemma":0.0009303404,"domain_scores_codex":[0.9997782,0.00006447952,0.00002809216,0.00003905901,0.00005095508,0.00003913776],"domain_scores_gemma":[0.999864,0.00004829744,0.00002286594,0.00003297204,0.00001484519,0.0000169635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005301029,0.00001547493,0.0001533131,0.00001339798,0.000002218447,0.00001835148,0.0000120401,0.00002561279,0.9993876,0.000051416,0.00002641087,0.000240972],"study_design_scores_gemma":[0.000007961226,0.0001663806,0.003203691,0.000003614399,0.00000541248,0.0001082789,0.00003263739,0.0003749554,0.9942557,0.00001262684,0.00182592,0.000002771969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989444,0.0007707769,0.004918178,0.00007881156,0.00003598109,0.00006347083,0.001409819,0.0001271931,0.003151872],"genre_scores_gemma":[0.9834547,0.0004761514,0.006309684,0.00007022161,0.00001586005,0.00009195119,0.003520452,0.00005499555,0.006006029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001883173,"threshold_uncertainty_score":0.006299853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157518867235061,"score_gpt":0.2338001852139853,"score_spread":0.2180482984904792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}