{"id":"W3169902646","doi":"10.1101/2021.06.16.448722","title":"Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services","funders":"National Cancer Institute; John S. Dunn Gulf Coast Consortium for Chemical Genomics; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"PLK1; Cancer research; Biology; Breast cancer; Gene knockdown; Kinase; Cancer; Cell cycle; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004550412,0.0005835652,0.0005415667,0.0004721856,0.0001414893,0.0006018649,0.0002552886,0.0003959957,0.001559851],"category_scores_gemma":[0.0003605165,0.0001459757,0.0002464038,0.0002399988,0.0002765629,0.0004399138,0.0002390743,0.0008067045,0.0003848871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005895551,"about_ca_system_score_gemma":0.0002195389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002137946,"about_ca_topic_score_gemma":0.0002706087,"domain_scores_codex":[0.9998509,0.00002394466,0.00001949857,0.00003825156,0.0000466165,0.00002079666],"domain_scores_gemma":[0.9998025,0.00002409087,0.00008592736,0.00001505106,0.00002726934,0.00004507149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003242903,0.0002522068,0.02983483,0.0001934284,0.00006839295,0.000300388,0.00002608112,0.0006933308,0.9478414,0.0001551949,0.0005149116,0.01687698],"study_design_scores_gemma":[0.0002333681,0.004080226,0.1082818,0.00004958754,0.0002363524,0.003219865,0.0001017547,0.007961034,0.869882,0.0004858326,0.005435686,0.00003255331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897705,0.004683633,0.002740743,0.0005705265,0.00006787389,0.00007631828,0.0005409397,0.0002525874,0.001296961],"genre_scores_gemma":[0.9970944,0.0004919287,0.001179654,0.0001175863,0.00001513061,0.00003321279,0.0003142391,0.0000158995,0.0007380303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559851,"threshold_uncertainty_score":0.005218208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131731266213888,"score_gpt":0.2610117191568522,"score_spread":0.2478385925354634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}