{"id":"W3169979944","doi":"10.1096/fasebj.2021.35.s1.02818","title":"<i>Entamoeba histolytica</i> ‐Induced Activation of Caspase‐4 Regulates Gasdermin D Cleavage to Mediate IL‐1β Secretion in Macrophages","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inflammasome; Secretion; Caspase 1; Cell biology; Pyroptosis; Entamoeba histolytica; Chemistry; Caspase; Effector; Biology; Programmed cell death; Biochemistry; Microbiology; Apoptosis; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929166,0.0002969486,0.0002926518,0.0001621461,0.0001654408,0.0004055805,0.0001561697,0.0003228742,0.001658328],"category_scores_gemma":[0.0001315756,0.000121618,0.0004218585,0.0001293874,0.000285962,0.0002917793,0.0002665513,0.0005818681,0.0006652726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003997177,"about_ca_system_score_gemma":0.0001974302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004451144,"about_ca_topic_score_gemma":0.0004919143,"domain_scores_codex":[0.9997336,0.00004656292,0.0000317903,0.00004677111,0.00004364081,0.00009752929],"domain_scores_gemma":[0.9999121,0.00001089741,0.00002988238,0.00001073203,0.00001680419,0.00001952718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002049883,0.0000301849,0.0002393432,0.00006081704,0.000004841463,0.00007056967,0.00001723054,0.0000263599,0.9987535,0.0000705564,0.00005798649,0.0004635459],"study_design_scores_gemma":[0.00003807367,0.0002906524,0.01482219,0.00001491275,0.0000147059,0.0005040054,0.0001243381,0.001084721,0.979782,0.0001296446,0.003185596,0.000009051641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912192,0.002354538,0.003171601,0.0002782613,0.00006270174,0.00005462147,0.0005154708,0.00009069466,0.002252859],"genre_scores_gemma":[0.9946092,0.0007214736,0.001536348,0.0001959263,0.00001833123,0.00005550137,0.0006574714,0.00001748544,0.002188204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658328,"threshold_uncertainty_score":0.005547643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728458129357112,"score_gpt":0.2704465013903504,"score_spread":0.2531619200967792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}