{"id":"W3170014096","doi":"10.1093/neuonc/noab090.147","title":"TMOD-06. LOSS OF DICER COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE METASTATIC MEDULLOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Dicer; Biology; PTEN; Medulloblastoma; Cancer research; Carcinogenesis; Glioma; microRNA; Tumor progression; Tumor initiation; Cancer; Genetics; Small interfering RNA; PI3K/AKT/mTOR pathway; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002185088,0.00033192,0.000338798,0.0003827103,0.0001547455,0.0003296646,0.0002830901,0.0003701344,0.001332338],"category_scores_gemma":[0.0001758839,0.000233011,0.0003243369,0.0001525798,0.0002608118,0.0001677244,0.0002664888,0.0007300987,0.000684961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465208,"about_ca_system_score_gemma":0.0002046704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004664962,"about_ca_topic_score_gemma":0.0008115631,"domain_scores_codex":[0.9996811,0.00003922438,0.00005029646,0.00007990198,0.00008750294,0.00006206201],"domain_scores_gemma":[0.9996358,0.00005172157,0.0001239849,0.00005199838,0.0000189442,0.0001175209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003767334,0.00001801718,0.0001312256,0.00001048752,0.000002370486,0.00005715036,0.000005352085,0.00003204833,0.9992965,0.00004467012,0.00001972658,0.0003447702],"study_design_scores_gemma":[0.0000115906,0.0002126443,0.002547301,0.000002180931,0.000006398947,0.0003638001,0.00001457856,0.000797319,0.9945411,0.00001752523,0.001482572,0.000002954316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929598,0.00062709,0.003852949,0.00008511924,0.000030308,0.00006205936,0.0009125167,0.0002270645,0.001243161],"genre_scores_gemma":[0.9926957,0.0002426901,0.002787872,0.00003893001,0.00000586425,0.00005868024,0.000833335,0.00006974713,0.003267251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332338,"threshold_uncertainty_score":0.004457116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149799367318036,"score_gpt":0.3010828824536738,"score_spread":0.2861029457218702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}